the polysaccharides of acanthophora spicifera and cystoseira trinode were isolated and theircomponents identified using different chemical and spectral techniques. their effects were evaluated for thefirst time on hyperlipidemic rats. atorvastatin ca (lipitor®) was used as a reference drug. results revealedthat the polysaccharides isolated were of sulfate type. acanthophora spicifera lowered th...

The influence of hyperlipidemic sera on prostacyclin (PGI2) production by cultured endothelial cells was assessed by comparing sera from three types of hyperlipidemias with sera from normal subjects. Sera prepared from normal whole blood (WBS), platelet-rich plasma (PRPS), and platelet-poor plasma (PPPS) were also compared. Bovine aortic endothelial cells (BAEC) incubated with 25% WBS increased...

To assess determinants of blood pressure and racial differences in blood pressure in hyperlipidemic children, and to compare blood pressure in hyperlipidemic and random recall groups of children, studies were carried out on 513 school children (ages 6 through 19 years), and 309 adults (ages 20 through 64), recalled by virtue of elevated cholesterol or triglyceride levels in the Cincinnati Lipid...

The study was aimed to investigate the effect of dissolution enhancement on hypolipidemic and hepatotoxicity drug in hyperlipidemic rats. Atorvastatin ascorbic acid cocrystals were prepared by phase solution methods characterized Fourier transformation infrared spectroscopy, differential scanning calorimetry, electron microscopy, X-Ray powder diffraction. Results characterization confirmed that...

background: type 2 diabetes mellitus with hyperlipidemia is a common disease. conventional anti-hyperglycemic and anti-hyperlipidemic drugs have limited efficacies and important side effects, so that alternative agents are needed. previous studies suggest that fiber-free artichoke (cynara scolymus l.) leaf extract may have anti-hyperglycemic and anti-hypercholesterolemic effects in hypercholest...

Li T, Yang G, Zhu Y, Wu Y, Chen X, Lan D, Tian K, Liu L. Diabetes and hyperlipidemia induce dysfunction of VSMCs: contribution of the metabolic inflammation/miRNA pathway. Am J Physiol Endocrinol Metab 308: E257–E269, 2015. First published November 25, 2014; doi:10.1152/ajpendo.00348.2014.—Vascular endothelial cell injury is considered to be the major factor inducing vascular complications in m...

This study aims to evaluate the benefit of combined administration of sodium molybdate with atorvastatin in management of hyperlipidemia. Hyperlipidemic male Serian golden hamsters were administered either atorvastatin (40 or 80 mg/kg, p.o.) sodium molybdate (100 mg/kg, p.o.) or combination of atorvastatin (40 mg/kg, p.o.) with sodium molybdate (100 mg/kg, p.o.) for 30 consecutive days. Blood l...

OBJECTIVE Transplant arteriosclerosis (TA) restricts long-term survival of heart transplant recipients. Although the role of monocyte/macrophages is well established in native atherosclerosis, it has been studied to a much lesser extent in TA. Plasma cholesterol is the most important non-immunologic risk factor for development of TA but the underlying mechanisms are largely unknown. We hypothes...

Several studies have previously reported high levels of total tissue factor pathway inhibitor (TFPI) antigen in patients with hypercholesterolemia. The relationship between serum lipid concentrations and total and free-form TFPI antigen in 32 patients with primary type II hypercholesterolemia and 38 ageand gender-matched normolipemic control subjects was studied (Study Group I). Plasma concentr...

BACKGROUND Small dense low-density lipoprotein (sdLDL), which has a small LDL particle size with a greater susceptibility to oxidation, is considered a risk marker for cardiovascular disease (CVD). The diacron reactive oxygen metabolites (d-ROMs) have recently been introduced as a clinically useful oxidative stress-related marker. Physical activity can reduce the CVD risk. The present study inv...