limiting intracellular enzyme for nicotinamide adenine dinucleotide (NAD) synthesis starting from nicotinamide [1]. The plasma Nampt levels are reported to have correlation with obesity and obese related metabolic disease, such as Type 2 diabetes mellitus (T2DM), cardiovascular diseases [2] and hyperlipidemia [3] due to association with lipoprotein and cholesterol. Therefore, sensitive detectio...

OBJECTIVE To determine whether retinal vein occlusion (RVO) is related to systemic hypertension, diabetes mellitus, and hyperlipidemia. METHODS We systematically retrieved all studies published between January 1985 and July 2007 that compared cases with any form of RVO, including central and branch RVO, with controls. We generated pooled odds ratios (ORs) and estimates of the population-attri...

BACKGROUND Little is known about how Medicare Part D affects the medication refill adherence for cardiovascular and diabetes medications, particularly among beneficiaries without prior drug coverage. OBJECTIVES To evaluate Medicare Part D's effect on medication adherence among beneficiaries with hyperlipidemia, hypertension, and/or diabetes enrolled in Medicare Advantage products. RESEARCH ...

The hypolipidemic activity of Lepidium sativum (family: Brassicaceae) seed sapogenin and flavonoid extract (LSTS and LSTF) was studied against Triton x-100 and high cholesterol diet (HCD) induced hyperlipidemia on rats. The parameters assessed were serum total protein, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDLc), low density lipoprotein cholesterol (LD...

INTRODUCTION AND OBJECTIVES The aim of this study was to determine the accuracy of self-reported diabetes, hypertension and hyperlipidemia in a representative sample of adults (719 men and 837 women) from the south of Spain. METHODS Self-reported data were gathered using a structured questionnaire. Biometric data recorded included blood glucose, total cholesterol and triglyceride concentratio...

Combined hyperlipidemia may result from the interaction of several metabolic and environmental factors. We explored to what extent fasting insulin concentration, apolipoprotein (apo) E2 frequency, and cigarette smoking explained the serum levels of triglyceride and high-density lipoprotein cholesterol (HDL-C) in patients with combined hyperlipidemia. Forty-nine untreated patients with combined ...

BACKGROUND Bezafibrate (BZF) is effective in the treatment of hypertriglyceridemia in human patients, but there are no data on its use in dogs. OBJECTIVE To assess the safety of BZF in hyperlipidemic dogs and its efficacy in decreasing serum triglyceride (TG) and cholesterol (CHO) concentrations. ANIMALS Forty-six dogs, 26 females and 20 males, mean (±SD) age of 9 (±3) years, with TG ≥150 m...

To evaluate the clarithromycin pharmacokinetics after atorvastatin single and repeated dose administration in induced hyperlipidemic Wistar rats. A standard cholesterol diet (2% cholesterol) was used to induce hyperlipidemia and feed was given to rats for 6-8 weeks. Group’s allocation as follows: G1-G3: Induced hyperlipidemic rats pretreatment of atorvastatin as a single dose followed by clarit...

Insulin resistance has been associated with hypertriglyceridemia, combined hyperlipidemia, and familial combined hyperlipidemia (FCHL). Whether all FCHL patients with different types of dyslipidemia have low insulin sensitivity has not been evaluated. We measured insulin sensitivity by the hyperinsulinemic euglycemic clamp with indirect calorimetry in 110 healthy controls and in 105 nondiabetic...

BACKGROUND Cardiovascular disease (CVD) is the leading cause of death in Russia. Hypertension and hyperlipidemia are important risk factors for CVD that are modifiable by pharmacological treatment and life-style changes. We aimed to characterize the extent of the problem in a typical Russian city by examining the prevalence, treatment and control rates of hypertension and hyperlipidemia and inv...