Background and Objective: Parkinson’s disease (PD) is a rather common neurological disorder in elders that is due to degeneration of dopaminergic neurons within mesencephalic substantia nigra pars compacta. With regard to protective and antioxidant effect of simvastatin, this study was conducted to evaluate its neuroprotective effect in an experimental model of PD. Materials and Methods: In thi...

Neurodegeneration is one of the primary etiologies in the onset of Parkinson's disease. In the quest for a new antiparkinsonism treatment the potential benefits of puerarin from the roots of Pueraria lobata have been recognized. Thus, we examined whether puerarin is capable to protect dopaminergic neurons of the substantia nigra against 6-hydroxydopamine induced neuronal cell death. Our data sh...

Hypericum perforatum L. (Hypericaceae) is one of the medicinal plants whose value has increased rapidly in recent years. It especially popular for its use treatment mild and moderate depression, as well skin diseases, internal external inflammatory wounds, neurological disorders, metabolism-disrupting effects free radicals. Besides, it shows inhibitory against different kinds microorganisms suc...

Hypericum perforatum L. is a medicinal plant considered as an important natural source of secondary metabolites with a wide range of pharmacological attributes. Hairy roots (HR) were induced from root segments of in vitro grown seedlings from H. perforatum after cocultivation with Agrobacterium rhizogenes A4. Investigations have been made to study the production of phenolic compounds in dark-gr...

Hypericumperforatum (H. perforatum) ethanol extract has been found to inhibit lipopolysaccharide-induced production of inflammatory mediators and cytokines in cultured macrophages. Therefore, it may be able to protect the host from excessive inflammation during viral infection. In the current study, the immune-regulatory effect of H. perforatum extract was evaluated in A549 lung epithelial cell...

Monoamine oxidase (MAO) catalyzes the oxidative deamination of amines and neurotransmitters and is involved in mood disorders, depression, oxidative stress, and adverse pharmacological reactions. This work studies the inhibition of human MAO-A by Hypericum perforatum, Peganum harmala, and Lepidium meyenii, which are reported to improve and affect mood and mental conditions. Subsequently, the an...

John Hick has used revolutionary metaphors in recommending his pluralistic philosophy of religions. To turn from a focus on the particulars of one’s home religion to a focus on the universally available Real is, he famously says, a Copernican “revolution” in religious thought. Hick says that those religious adherents who abandon the traditional positions of exclusivism or inclusivism, positions...

St. John’s wort (SJW)(Hypericum perforatum L) is one of the oldest medicinal herbs. Hypericum extracts have been shown to be significantly effective in treating mild to moderate depression. To our knowledge, this is the first case report about panic attack in a man induced by a single dose of SJW extract. A 35-year-old male was admitted for gradually increased trembling and fear of dying. He st...