نتایج جستجو برای: hyperhomocysteinemia
تعداد نتایج: 2497 فیلتر نتایج به سال:
Homocysteine is a sulfur-containing, nonproteinogenic amino acid biosynthesized from methionine which has a key place in common between the folate cycle and the activated methyl cycle. Homocysteine export into the extracellular medium reflects an imbalance between homocysteine production and metabolism (1). Hyperhomocysteinemia has been associated with folate or cobalamine deficiencies, and als...
RATIONALE Patients with chronic kidney disease (CKD) develop hyperhomocysteinemia and have a higher cardiovascular mortality than those without hyperhomocysteinemia by 10-fold. OBJECTIVE We investigated monocyte differentiation in human CKD and cardiovascular disease (CVD). METHODS AND RESULTS We identified CD40 as a CKD-related monocyte activation gene using CKD-monocyte -mRNA array analys...
BACKGROUND Patients with chronic kidney disease (CKD) show a risk of cardiovascular death, which is 10-100 times higher than that in the general population. This increase is not completely explained by the traditional cardiovascular risk factors. Hyperuricemia and hyperhomocysteinemia are highly prevalent in CKD. Patients suffering from these complications present accelerated atherosclerosis, d...
We examined effects of hyperhomocysteinemia on structure and mechanics of cerebral arterioles. We measured plasma total homocysteine (tHcy) and pressure, diameter, and cross-sectional area of the vessel wall in maximally dilated cerebral arterioles in heterozygous cystathionine -synthase–deficient (CBS / ) mice and wild-type (CBS / ) littermates that were provided with drinking water that was u...
Impaired transfer of methyl groups via the methionine cycle leads to plasma hyperhomocysteinemia. The tissue sources of plasma homocysteine in vivo have not been quantified nor whether hyperhomocysteinemia is due to increased entry or decreased removal. These issues were addressed in female rats offered diets with either adequate or excess methionine (additional methyl groups) with or without f...
BACKGROUND Retinopathy is the leading cause of blindness among patients with type 2 diabetes mellitus (DM). Hyperhomocysteinemia is a recently recognized risk factor for cardiovascular disease, independent of established risk factors. OBJECTIVE To study the association between the homocysteine level and retinopathy among subjects with and without DM. METHODS We studied an age-, sex-, and gl...
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