This article studies a contemporary treatment approach toward both diabetes and depression management by vanadium-enriched Cordyceps sinensis (VECS). Streptozotocin-induced hyperglycemic rats were used in the study. After the rats were administered with VECS, a significant reduction in blood glucose levels was seen (P < .05) and the levels of serum insulin increased significantly (P < .05). At ...

Vatharasavangam (VRV) is a hypoglycemic drug mentioned in the Siddha Literature. Previous studies showed that VRV therapy brings down the blood glucose levels in the hyperglycemic rabbits. The present intestinal perfusion studies with labelled glucose indicate that the blood glucose homeostatis in VRV treated animals is brought about by a significant reduction in the rate of glucose absorption ...

BACKGROUND Cataracts are generally known to occur in hyperglycemic conditions in diabetic patients. In this case, cataract occurred in the course of glucose level control in a patient who had been in a hyperglycemic state. CASE PRESENTATION A 42-year-old Korean man who had uncontrolled diabetes for more than a year presented with bilateral posterior subcapsular cataracts, which developed with...

The whole plant aqueous extract of E. littorale was tested for its hypoglycemic activity on normoglycemic, hyperglycemic and alloxan induced diabetic rats. Blood sugar lowering activity was not observed in normoglycemic and glucose loaded hyperglycemic rats in the short time experiment. But in case of diabetic rats, the fall of blood sugar after 30 days treatment with the aqueous extract was fo...

Human type 2 diabetes is associated with β-cell apoptosis, and human islets from diabetic donors are ∼80% deficient in PAK1 protein. Toward addressing linkage of PAK1 to β-cell survival, PAK1-siRNA targeted MIN6 pancreatic β-cells were found to exhibit increased caspase-3 cleavage, cytosolic cytochrome-C and the pro-apoptotic protein Bad. PAK1(+/-) heterozygous mouse islets recapitulated the up...

The article by Van Herpe and colleagues in the previous issue of Critical Care describes the glycemic penalty index (GPI), which weights both hyperglycemic and hypoglycemic blood glucose measurements commensurate to their clinically significant difference from target. Although certain adverse consequences result from isolated severe hyperglycemic episodes, several specific outcomes depend upon ...

Impaired wound healing is among the serious complications of diabetes that can lead to amputation and even death. Plantago major has been used empirically improve healing. The main bioactive compounds P. extracts, ursolic acid (UA) oleanolic (OA), have also studied for their benefits with non-hyperglycemic wounds. This study was done examine in vivo effects leaf extracts (PMLE), UA, OA hypergly...