نتایج جستجو برای: hydroxylase deficiency

تعداد نتایج: 152075  

Journal: :The Journal of biological chemistry 1975
S Murad Y Kishimoto

Alpha Hydroxylation of lignoceric acid (n-tetracosanoic acid) to cerebronic acid (2-hydroxylignoceric acid) by postnuclear preparations of brains from developing rat, mouse, and several neurological mouse mutants was studied. The preparations of brains from jimpy and myelin synthesis deficiency (msd) mice were found to synthesize cerebronic acid at less than 10 percent of their control rates, a...

Journal: :Annals of neurology 2007
Marcel M Verbeek Gerry C H Steenbergen-Spanjers Michèl A A P Willemsen Frans A Hol Jan Smeitink Jürgen Seeger Padraic Grattan-Smith Monique M Ryan Georg F Hoffmann Maria A Donati Nenad Blau Ronald A Wevers

Tyrosine hydroxylase (TH) deficiency (OMIM 191290) is one cause of early-onset dopa-responsive dystonia. We describe seven cases from five unrelated families with dopa-responsive dystonia and low homovanillic acid in cerebrospinal fluid who were suspected to suffer from TH deficiency. Analysis of part of the TH promotor showed five homozygous and two heterozygous mutations in the highly conserv...

Journal: :Annals of clinical and laboratory science 1982
R Matalon K Michals C L Lee J C Nixon

The newborn screening for phenylketonuria (PKU) has become a common practice in many countries. The success of this type of mass screening is the result of the reliability of the Guthrie test in the identification of high blood phenylalanine levels. Recently, new syndromes other than PKU have been recognized that give high blood phenylalanine levels. These syndromes are referred to as “atypical...

Journal: :The American Journal of Human Genetics 1998

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