Human peripheral blood leukocytes, activated by phorbol myristate acetate, disrupt canine sarcoplasmic reticulum calcium transport, in vitro, by an oxygen-derived free radical mechanism. Activated leukocytes significantly depress Ca++ uptake activity and Ca++ -stimulated, Mg++ -dependent ATPase activity. The depression is completely inhibited by sodium-azide (0.1 mM) or the combination of super...

T he discovery of superoxide dismutasel provided a highly specific probe for the implication of the superoxide free radical (O2) in numerous biological processes. From the beginning, though, there were those who were disquieted by the rather robust nature of the damage that was apparently inflicted by this relatively mild-mannered radical. Soon, evidence suggested that superoxide radical was no...

増 田高広,岩 下尚美,篠 原広行,近 藤 正春:東 京都立大学理学部化学科 東京 都世田谷区深沢2-1-1 T158 Reactivity of dipeptide/Hydroxyl radicals/Rate constant Rate constants for reactions of hydroxyl radicals with several glycyl-amino acids were determined by a competition method using p-nitrosodimethylailine as a reference compound. For glycyl-aliphatic amino acids, the enhancement of reactivity was observed as compared with the corres...

To investigate the ulcer protective and antisecretory properties of the methanolic extract of Butea monosperma (BM) bark with relation to antioxidant studies. The study was done on male albino rats.   Gastric ulcers were induced by Aspirin, Alcohol and Pylorous ligation. Lansoprazole was used as the standard drug for comparison. The free radical scavenging potential of the bark of BM ...

Pharmaceutical compounds and metabolites are being found in surface and ground waters which is indicative of inefficient removal by conventional wastewater treatment technologies. Advanced oxidation processes (AOPs), which utilize free-radical reactions to degrade chemical contaminates, are an alternative to traditional water treatment. Three fluoroquinolone pharmaceutical compounds were studie...

Hispidin oligomers are styrylpyrone pigments isolated from the medicinal fungi Inonotus xeranticus and Phellinus linteus. They exhibit diverse biological activities and strong free radical scavenging activity. To rationalize the antioxidant activity of a series of four hispidin oligomers and determine the favored mechanism involved in free radical scavenging, DFT calculations were carried out a...

Hydroxybenzylidene hydrazines exhibit a wide spectrum of biological activities. Here, we report synthesis and free radical scavenging activity of nine new N-(hydroxybenzylidene)-N'-[2,6-dinitro-4-(trifluoromethyl)]phenylhydrazines. The chemical structures of these compounds were confirmed by 1H-NMR, 13C-NMR, 19F-NMR, IR spectroscopy, LC-MS, and elemental analysis. The prepared compounds were te...

The antioxidant and antimutagenic properties of the extract from the oriental natural drug - Belamcanda chinensis (L.)DC. (Iridaceae) rhizomes have been examined. Three different antioxidant assays and Salmonella antimutagenic test have been used. The extract has strong free radical scavenging activity as shown by the DPPH assay with EC50 of 63.4 microg/mL. Similarly, the high ability to reduce...

ABSTRACT Three 2'-aminochalcone derivatives (E)-1-(2-aminophenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one, (E)-1-(2-aminophenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one, and (E)-1-(2-amino-4,5-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one, have been synthesized, characterized, and tested in vitro in order to assess their antioxidant activity. All compounds were characterized on the basis of 1H ...