Combination of cyclosporin (CyA) with the prevailing therapy was studied in 32 children with severe and refractory juvenile idiopathic arthritis (JIA). Although blood erythrocyte sedimentation rate (ESR) and the serum concentration of the C-reactive protein (CRP) improved significantly (p<0.05 and <0.001, respectively), the hospitalization days, oral dose of prednisolon and intra-articular inje...

Background: Hydroxychloroquine (HCQ) is a well-tolerated drug that contributes to downregulating the immune response against autoantigens and it has been used in several autoimmune diseases. In systemic sclerosis (SSc) treat inflammatory arthritis without proof of efficacy. Objectives: Our aim was evaluate use HCQ its impact on Health Assessment Questionnaire disability index (HAQ-DI) Cochin Ha...

Objective To evaluate the usefulness of biomarkers to predict evolution patients suspected systemic lupus erythematosus (SLE), designated as probable SLE (pSLE), into classifiable according American College Rheumatology (ACR) classification criteria. Methods Patients were enrolled by experts if they fulfilled three ACR criteria for and followed approximately 1-3 years transition ACR-classifiabl...

PURPOSE To report expanded SD-OCT findings of HCQ retinopathy that may assist the clinician in earlier diagnosis. To characterize structural changes of HCQ retinopathy with SD-OCT after drug cessation. METHODS Setting: Private practice and academic institution. Patient Population: Patients at New England Eye Center and Ophthalmic Consultants of Boston in Boston, MA diagnosed with HCQ retinopa...

Background: Systemic lupus erythematosus (SLE) could affect multiple parts of the eye. (1,2) Also, there is risk ocular toxicity associated with treatment, such as hydroxychloroquine.(3) Early diagnosis essential to avoid major complications. However, complaints eye discomfort may be vague, and various presentations pose challenges on rheumatologists. Knowing real-world prevalence problems in p...

We appreciate the interest shown by Pareek and Chandurkar concerning our recent study on diabetes mellitus (DM) risk associated with disease-modifying antirheumatic drugs and statins in patients with rheumatoid arthritis (RA). They pointed out that statin-associated DM risk in patients with RA might be a more important concern than the risk attributed to glucocorticoids (GCs) due to longer trea...

During the early stages of COVID-19 pandemic, many cities throughout world observed a marked increase in sudden cardiac death (SCD). The p.S1103Y-SCN5A common variant, present ∼8-10% individuals African descent, may be circumstance-dependent, SCD-predisposing, pro-arrhythmic polymorphism setting hypoxia-induced acidosis or QT-prolonging drug use. In light FDA’s Emergency Use Authorization hydro...

The aim of our study was to characterize the repolarization disorders propensity induced by drug-drug interaction. In this observational retrospective study, we report experience on all elderly patients with ascertained diagnosis coronavirus disease 2019 through nasopharyngeal swab real time-polymerase chain reaction at Pugliese-Ciaccio hospital in Catanzaro, who received hydroxychloroquine (HC...

Background The COVID-19 pandemic has taken a toll on the mental health of general population. Patients with systemic lupus erythematosus (SLE) were particularly exposed due to many uncertainties linked virus and their immunosuppression as well difficulties access medical care treatment (eg, hydroxychloroquine) during early pandemic. Objectives To evaluate encountered by SLE patients pandemic, i...