losartan potassium is a well known orally active non-peptide angiotensin ii receptor antagonist. losartan potassium and its principle active metabolites block the vasoconstrictor and aldosterone secreting effect of angiotensin ii by selectively blocking the binding of angiotensin ii to at1 receptors. the drug is reported to promote the decrease in ventricular hypertrophy, salt and water excreti...

Objective: The main objective of the current research work was to formulate and evaluate Bosewellia serrata extract loaded transferosomal topical gels. To overcome drawbacks associated with oral administration in Osteoarthritis treatment. Methodology: Transferosomes were developed using different ratios Phospholipon® 90G as phospholipid, Span-60 surfactant cholesterol fluidity buffer. selected ...

UNLABELLED BACKGROUND Diets producing a high glycemic response result in exaggerated insulin secretion which induces hepatic lipogenesis, contributing to development of insulin resistance and fatty liver. Viscous dietary fibers blunt the postprandial rise in blood glucose, however their effect on type 2 diabetes and obesity are not entirely known. This study examined the effect of chronic co...

Microcrystals of piroxicam (PRX) monohydrate with a narrow size distribution were prepared from acetone/PRX solutions by antisolvent crystallization via metallic membranes with ordered pore arrays. Crystallization was achieved by controlled addition of the feed solution through the membrane pores into a well-stirred antisolvent. A complete transformation of an anhydrous form I into a monohydrat...

CE methods with capacitively coupled contactless conductivity detection (C(4)D) were developed for the enantiomeric separation of the following stimulants: amphetamine (AP), methamphetamine (MA), ephedrine (EP), pseudoephedrine (PE), norephedrine (NE) and norpseudoephedrine (NPE). Acetic acid (pH 2.5 and 2.8) was found to be the optimal background electrolyte for the CE-C(4)D system. The chiral...

PURPOSE To investigate the suitability of an SCMC (sodium carboxymethyl cellulose/polyethylene glycol 400/carbopol 934P) and an HPMC (hydroxypropylmethyl cellulose/polyethylene glycol 400/carbopol 934P) films as drug vehicle for buccal delivery. METHODS The mechanical and in vitro bioadhesive strength properties of the films were investigated using texture analyzer equipment, while swelling b...

Gastroretentive drug delivery system i.e. floating microspheres of an H2 receptor antagonist drug ‘famotidine’ was successfully prepared using combination of polymer as hydroxyl propyl ethyl cellulose K15M (HPMC K15M) and cellulose acetate via non-aqueous solvent evaporation (oil-in-water) technique. Famotidine loaded floating microsphere formulations were prepared by dissolving polymer in solv...

phorbiaceae. It is a shrub or small tree reaching 4—5 meters high and native to Thailand, where it is commonly called “Plao phae”. In this paper, we describe the isolation and structure elucidation of newly isolated 3 -(4 -hydroxy-3 ,5 dimethoxyphenyl)-propyl benzoate, 3 -(4 -hydroxyphenyl)propyl benzoate and four known compounds [3 -(4 -hydroxy-3 -methoxyphenyl)-propyl benzoate, poilaneic acid...

The use of uncoated fused silica capillary columns and hydroxypropylmethyl cellulose (HPMC) in capillary electrophoresis (CE) to separate DNA ladders and plasmids is described. In these studies HPMC is used as a sieving matrix to separate DNA. Many previous studies have focused on using coated and gel-filled capillaries to *Correspondence: F. A. Gomez, Department of Chemistry and Biochemistry, ...