Novel approaches in synthesis of spherical and multispiked gold nanoparticles coated with polyethylene glycol (PEG) and pH Low Insertion Peptide (pHLIP®) were introduced. The presence of a tumor-targeting pHLIP® peptide in the nanoparticle coating enhances the stability of particles in solution and promotes a pH-dependent cellular uptake. The spherical particles were prepared with sodium citrat...

Skeletal muscle is an interesting target for gene therapy. To achieve effective gene introduction in skeletal muscle, a hydrodynamic approach by intravenous injection of plasmid DNA (pDNA) with transient isolation of the limb has attracted attention. In this study, we demonstrated that polyplex nanomicelle, composed of poly(ethyleneglycol) (PEG)-block-polycation and pDNA, showed excellent capac...

Motivated by magnetic polymer manufacturing applications, the present research article examines theoretically hydromagnetic boundary layer flow of an electrically conducting non-Newtonian couple stress fluid due to a transient shrinking (contracting) porous sheet. The conservation partial differential equations for mass and momentum are rendered into fifth-order nonlinear ordinary equation via ...

The present paper contains the test results of a planing catamaran model. The aim of the tests was to study the effect of hydrofoil in these types of crafts. First, experiments were carried out on the bare body (i.e. without hydrofoils) to obtain non-dimensional hydrodynamic resistance coefficient versus speed. Then, the model with hydrofoils, by various locations and attack angles were subject...

The effect of the asymmetric water entry over a submerged part of a ship on the hydrodynamic impact is investigated numerically. A wedge body is considered to study and the problem is assumed to be two-dimensional. The Results of symmetric and asymmetric impacts are compared together. The effect is found significant in the numerical simulation. The maximum hydrodynamic pressure at a heel angle ...

Pressure assisted capillary electrophoresis in capillaries with internal diameters of 10 μm was found possible without significant penalty in terms of separation efficiency and sensitivity when using contactless conductivity detection. A sequential injection analysis manifold consisting of a syringe pump and valves was used to impose a hydrodynamic flow in the separation of some inorganic as we...

A mouse model of hepatitis B virus (HBV) infection produced by hydrodynamic injection of HBV DNA has been recently established. However, the ultrastructural demonstration of HBV particles in this mouse model has not as yet been reported. In our study, plasmid DNA containing wild-type HBV DNA was rapidly injected into 8-week-old female SCID mice via the tail vein. Serum levels of HBsAg were meas...