INTRODUCTION Complete Hydatidiform mole is one of the most frequent abnormal pregnancies. This review studies the trend of complete mole in Paropakar Maternity and Women's hospital and clinical ability to detect it. METHODS This is a retrospective study of 504 cases of complete hydatidiform mole recorded at Paropakar maternity and women's hospital, Kathmandu, during 2058-2065 B.S. Medical rec...

A wide variety of plants contains enzymes capable of rapidly oxidizing l-lactic, glycolic, and glyoxylic acids (1). Although the enzyme oxidizing glycolic acid was found in the green parts of many plants, it was absent from roots and etiolated seedlings. However, the active enzyme could be obtained from etiolated barley or bean seedlings that had been illuminated for several hours. This suggest...

OBJECTIVE Can polymer-based immunohistochemical staining of p57(kip2) replace DNA analysis as an inexpensive means of differentiating complete mole from partial mole or hydropic abortion? METHODS AND MATERIALS Original paraffin-embedded tissue blocks from 14 equivocal cases were turned over to our laboratory and examined by immunohistochemical staining of p57(kip2). RESULTS Four of the 14 c...

After the discovery of eusociality in the naked mole-rat, it was proposed that inbreeding and high colony relatedness in this species were the major underlying factors driving cooperative breeding in African molerats. By contrast, field and laboratory studies of the eusocial Damaraland mole-rat (Cryptomys damarensis) have raised the possibility that this species is an obligate outbreeder, altho...

are of the greatest interest and importance; yet it must be confessed that attention has been paid to them by obstetricians only of recent years, and our knowledge is as yet of the scantiest description. The reason for this has probably been that the interest in such cases has been divided, the obstetrician being specially concerned with the clinical features, and only languidly hitherto in the...

acrjourna h levels of the critical p53 inhibitor Mdm4 is common in tumors that retain a wild-type p53 allele, ting that Mdm4 overexpression is an important mechanism for p53 inactivation during tumorigenesis. t this hypothesis in vivo, we generated transgenic mice with widespread expression of Mdm4. Two ndent lines of transgenic mice, Mdm4 and Mdm4, developed spontaneous tumors, the most prevf ...

Downlo an epidermal growth factor receptor 2 (HER2) overexpression stimulates cell growth in p53-mutated hile it inhibits cell proliferation in those with wild-type p53, but the molecular mechanism is wn. The Dmp1 promoter was activated by HER2/neu through the phosphatidylinositol-3′-kinaseF-κB pathway, which in turn stimulated Arf transcription. Binding of p65 and p52 subunits of was shown to ...

Hydatidiform moles are abnormal conceptions characterised by atypical hyperplastic trophoblasts and hydropic villi. Their incidence is approximately 1 in 1000 pregnancies. The recurrence risk of hydatidiform mole is approximately 1 in 60 in a subsequent pregnancy and 1 in 6.5 in the third pregnancy. In cases with recurrence, the majority of moles are of the same type as that in the preceding pr...

Moringa oleifera Lam (Moringaceae) is promising plant for biomedicine applications because it has an impressive range of medicinal purposes with high nutritional value. Therefore, we investigated the therapeutic effect of Moringa oleifera leaf extract (MOLE) on Ehrlich's solid tumor implanted mice (EST-mice). Swiss male albino mice were implanted intramuscularly with Ehrlich ascites carcinoma (...