High-risk types of human papillomavirus (HPV) are the causative agents of cervical cancer. Cervical screening could be improved by testing for the DNA of high-risk types of HPV as a primary screening tool. Authors: Cervical cancer is caused by high-risk types of human papillomavirus (HPV). DNA testing of such high-risk types of HPV could improve cervical screening. Background: High-risk types o...

OBJECTIVE The purpose of this study was to investigate the relationship between p16(CDKN2A) methylation and epithelial dysplasia (ED). We also evaluated the expressions of proteins related to methylation (DNMT3B and DNMT1). Finally, we tested whether HPV-16/18 or the dmt3b (C46359T) polymorphism is associated with p16(CDKN2A) methylation status. METHODS To test the hypothesis, a case-control ...

BACKGROUND High-risk human papillomaviruses (HPV) are the main etiological factor of cervical cancer. Cervical intraepithelial neoplasia grade 3 (CIN 3) is the latest pre-invasive stage of cervical cancer, with an approximately 20% progression rate to invasive cervical carcinoma. OBJECTIVE To establish the pre-vaccination distribution of HPV genotypes in Slovenian women with CIN 3 lesions, in...

BACKGROUND A large free-of-charge quadrivalent HPV (qHPV) vaccination program, covering four cohorts annually (women 11, 14, 17 and 24 years), has been implemented in Basilicata since 2007. This study evaluated vaccine and non-vaccine HPV prevalence 5-7 years post-vaccination program implementation in vaccinated and unvaccinated women. METHODS This population-based, cross-sectional study was ...

background cervical cancer is the leading cause of death from cancer in under-developed countries. human papilloma virus (hpv) 16 and 18 are the most prevalent types associated with carcinogenesis in the cervix. conventional polymerase chain reaction (pcr), type-specific and consensus primer-based pcr followed by sequencing, restriction fragment length polymorphism (rflp) or hybridization by sp...

human papillomavirus (hpv) has also been suggested as an etiology of esophageal squamous cell carcinoma (scc). the aim of this study was to investigate the prevalence of hpv infection in esophageal sccs in our region with strict contamination control to prevent false positive results. thirty cases of esophageal squamous cell carcinomas were chosen by simple random selection in a period of two y...

few studies have been conducted on the causative factors associated with the development of cancer. infection by high risk human papillomaviruses (hpvs) have been implicated as causative agents in a variety of cancers. hpv is capable of evading immune system and establishing persistent infections. prolonged infection and lesion maintenance are associated with higher risk of neoplastic progressi...

conclusions the results showed remarkable rates of high-risk hpv types (16 and 18) in the studied population, which can be a serious alert for public health. this result highlights the potential impact of prophylactic vaccines for future protection against high-risk hpv types in iranian women. materials and methods this cross-sectional population-based study consisted of two groups of women: no...

background: breast cancer is the malignancy in humans and other mammals. several risk factors are involved in their appearance such as higher hormone levels and obesity. identification of a mouse mammary tumor virus supports a viral etiology for breast tumors in animals. viruses have been implicated in the development of various cancers, but viral induction for formation breast cancer is contro...

The papillomavirus E2 proteins regulate viral replication, gene transcription, and genome maintenance by interacting with other viral and host proteins. From a yeast two-hybrid screen, we identified the cellular protein Tax1BP1 as a novel binding partner of human papillomavirus type 18 (HPV18) E2. Tax1BP1 also interacts with the HPV16 and bovine papillomavirus type 1 (BPV1) E2 proteins, with th...