Major histocompatibility complex (MHC) molecules are of central importance in regulating the immune response against tumors. In this study we used immunohistochemistry to study human leukocyte antigen (HLA) class I and II antigen expression in normal breast tissues and benign, preneoplastic, primary, and metastatic breast lesions using antibodies against beta-2-microglobulin (beta2-m), heavy-ch...

PURPOSE Because the expression of human leukocyte antigen (HLA) antigens is important for immunologic recognition of tumor cells, we determined expression of locus-specific HLA class I antigens in uveal melanoma and tested whether the level of HLA expression was related to prognosis or associated with known prognostic parameters. METHODS Expression of HLA-A and -B antigens was determined on 3...

Psoriasis is a multifactoral and heterogenetically inherited disease. The role of hereditary transmission is supported by familial association, twin studies, and correlation with human leukocyte antigens (HLA). Numerous studies have proved that B13, B17, Cw6, and DR7 antigens are positively associated with psoriasis. Cw6 antigen has been repeatedly indicated to be the most significant marker fo...

BACKGROUND Humanized mice able to reconstitute a surrogate human immune system (HIS) can be used for studies on human immunology and may provide a predictive preclinical model for human vaccines prior to clinical trials. However, current humanized mouse models show sub-optimal human T cell reconstitution and limited ability to support immunoglobulin class switching by human B cells. This limita...

the human leukocyte antigen-b27 is one of the class i molecules of the major histocompatibility complex which is strongly associated with ankylosing spondylitis (as) . the strength of the disease association with b27 varies markedly among racial and ethnic populations. it is an allele family, which constitutes about 31 subtypes, with a considerable geographic and ethnic difference in distributi...

The genes of the human Major histocompatibility complex (MHC) on the short area of chromosome 6, play a crucial role in the recognition of “self’ from “non-self”. In man this complex is referred to as the Human Leucocyte Antigen (HLA) system. These HLA antigens are grouped as Class I and Class II depending on their distribution on nucleated cells. HLA antigens (three of Class I, HLAs A, B and C...

Abstract Background Corneal transplantation is the most frequently performed in UK. Despite this, therapeutic value of matching human leukocyte antigen (HLA) subtypes for transplanted corneas remains controversial. Ocular immune privilege was originally deemed to render unnecessary; however, more recently, has demonstrated improved outcomes including graft success, amongst others. This systemat...

OBJECTIVE To determine the association between mediastinal fibrosis and human leukocyte antigen (HLA) genes. DESIGN Case-control study. SETTING Vanderbilt University Medical Center. SUBJECTS Nineteen consecutive patients with mediastinal fibrosis who presented to the pulmonary clinic at Vanderbilt University Medical Center from 1987 to 1996. The control subjects were 21,086 whites who wer...

asthma is a complex and multifactorial disorder. several studies have reported association between different hla- dqb1 and hla- drb1 alleles and allergic asthma. the aim of the present study was to investigate the association of hla-class ii alleles and haplotypes, with total serum ige and the results of the skin prick test in iranian children with allergic asthma. a total of 112 patients with ...