florid cutaneous papillomatosis (fcp), is a rare cutaneous marker of internal malignancy. the underlying cancer is usually intra-abdominal (most often gastric in origin), and evolves parallel to the fcp. there is a common association between fcp and the other two eruptive paraneoplastic syndromes, i.e.malignant acanthosis nigricans and the sign of leser-trelat. it seems possible that these synd...

objective(s): the oct4b1, as one of oct4 variants, is expressed in cancer cell lines and tissues more than other variants and plays an important role in apoptosis and stress (heat shock protein) pathways. the present study was designed to determine the effects of oct4b1 silencing on expressional profile of hsp40 gene family expression in three different human tumor cell lines. materials and met...

BACKGROUND ML 3000 ([2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid) is an inhibitor of both cyclooxygenase and 5-lipoxygenase in vitro, and shows promise as a novel non-steroidal anti-inflammatory drug (NSAID). Unlike conventional NSAIDs which are associated with gastric ulcerogenic effects, ML 3000 causes little or no damage to the gastric mucosa, even t...

Background and objectives: Cancer cell resistance to common chemotherapy agents is on rise. Plants are considered valuable sources of herbal drugs for cancer therapy. The present study was conducted to investigate the in vitro antioxidant, anti-proliferative, and apoptosis-inducing properties of clove (Syzygium aromaticum L.) extract in human gastric carcinoma (AGS). Methods: Crude ethanol extr...

background: oct4b1, a novel variant of oct4, is expressed in cancer cell lines and tissues. based on our previous reports, oct4b1 appears to have a crucial role in regulating apoptosis as well as stress response [heat shock proteins (hsps)] pathways. the aim of the present study was to determine the effects of oct4b1 silencing on the expression of high molecular weight hsps in three different h...

abstract   background: gastric cancer is the second most common cancer and also the second cancer related death all over the world. in recent years recorded data for tumor has shown a rise in the incidence of gastric cancer in young individuals. the present study was designed to compare some of the epidemiologic characteristics of individuals suffering from gastric cancer aged below and above f...

We investigated the inhibition of apoptosis and proliferation of poorly differentiated AGS gastric cancer cells by epigallocatechin-3-gallate (EGCG), to establish target genes for regulation by EGCG. The proliferation and apoptosis of AGS gastric cancer cells treated with EGCG were observed by cell counting kit (CCK)-8 and flow cytometry. Differential gene expression in AGS cells treated with E...

the postgastrectomy recurrence rate is as high as 30-65%, with 5-year overall survival rates of <20%. local recurrence is very common which occurs in 38-45% of cases. the most common sites of locoregional recurrence are the gastric remnant at the anastomosis, the gastric bed, and the regional nodes. the recurrence may occur as early and late events after gastrectomy. most recurrences are early,...

Autophagy is classified as type II programmed cell death and may participate in tumorigenesis. However, changes in autophagy-lysosome signaling and the relationship between the apoptotic cascade and gastric cancer cells have not been fully elucidated. The present study investigated the induction of autophagy in poorly differentiated human gastric adenocarcinoma. Immunoblotting revealed markedly...

Signal transducers and activators of transcription (STATs) belong to a family of transcription factors activated in response to cytokines and growth factors. Constitutive activation of STAT3 has been observed in a growing number of tumour-derived cell lines, as well as in tumor specimens from human cancers. Our aim was to determine the relationship between the expression of phosphorylated STAT3...