From the Bone and Stem Cell Research Group, CABMM, University of Zurich, 8057 Zurich, Switzerland, Spine Research Group, CABMM, University of Zurich, 8057 Zurich, Switzerland, Centre for Medical Biotechnology, Faculty of Biology and Geography, University Duisburg-Essen, 45117 Essen, Germany, Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich,...

PURPOSE Association between genetic variants in complement factor H (CFH), factor B (CFB), component 2 (C2), and in the ARMS2/HTRA1 region with age-related macular degeneration (AMD) comes mainly from studies of European ancestry and case-control studies of late-stage disease. We investigated associations of both early and late AMD with these variants in a population-based study of people aged ...

OBJECTIVES The exact aetiology and pathogenesis of microdamage-induced long bone fractures remain unknown. These fractures are likely to be the result of inadequate bone remodelling in response to damage. This study aims to identify an association of osteocyte apoptosis, the presence of osteocytic osteolysis, and any alterations in sclerostin expression with a fracture of the third metacarpal (...

OBJECTIVE To perform a genome-wide DNA methylation study to identify DNA methylation changes in osteoarthritic (OA) cartilage tissue. METHODS The contribution of differentially methylated genes to OA pathogenesis was assessed by bioinformatic analysis, gene expression analysis, and histopathologic severity correlation. Genome-wide DNA methylation profiling of >485,000 methylation sites was pe...