نتایج جستجو برای: htlv 1 protease

تعداد نتایج: 2785192  

Journal: :Journal of virology 1998
S L Tarsis M T Yu E S Parks D Persaud J L Muñoz W P Parks

Human T-cell lymphotrophic virus type 2 (HTLV-2), a common infection of intravenous drug users and subpopulations of Native Americans, is uncommon in the general population. In contrast with the closely related HTLV-1, which is associated with both leukemia and neurologic disorders, HTLV-2 lacks a strong etiologic association with disease. HTLV-2 does shares many properties with HTLV-1, includi...

Journal: :Antimicrobial agents and chemotherapy 2008
Emanuela Balestrieri Claudia Matteucci Arianna Ascolani Anna Piperno Roberto Romeo Giovanni Romeo Ugo Chiacchio Antonio Mastino Beatrice Macchi

There is currently little research and development of new compounds with specific anti-human T-cell leukemia virus type 1 (HTLV-1) activity. The few antiretrovirals that have been tested against HTLV-1 in vitro have already been developed into anti-human immunodeficiency virus (HIV) drugs. Here, we show the effects of a newly synthesized family of phosphonated nucleoside compounds, phosphonated...

Journal: :Antiviral therapy 2011
Natsumi Araya Katsunori Takahashi Tomoo Sato Tatsufumi Nakamura Chika Sawa Daisuke Hasegawa Hitoshi Ando Satoko Aratani Naoko Yagishita Ryoji Fujii Hiroshi Oka Kusuki Nishioka Toshihiro Nakajima Naoki Mori Yoshihisa Yamano

BACKGROUND Human T-lymphotropic virus type-1 (HTLV-1) is a human retrovirus that causes HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukaemia (ATL). A higher viral load in individuals with HTLV-1 infection increases their risk of developing HAM/TSP and ATL. Moreover, the high proviral load is associated with the clinical progression of HAM/TSP. Reduction...

Journal: :The Journal of infectious diseases 2000
M Cavrois A Gessain O Gout S Wain-Hobson E Wattel

In the spinal cord of patients with human T cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), infiltrating CD4(+) lymphocytes seem to be the major reservoir for the virus. Little, however, is known about the mechanisms by which HTLV-1 crosses the blood-brain barrier. An oligoclonal proliferation of HTLV-1-infected CD4 lymphoid T cells is present i...

Journal: :The Journal of infectious diseases 2008
Satohiro Matsumoto Kazumi Yamasaki Kenichiro Tsuji Satoshi Shirahama

BACKGROUND The rate of human T lymphotropic virus type 1 (HTLV-1) positivity among residents of Kamigoto, Japan, is extremely high (15%). Although the rate of Helicobacter pylori positivity in Kamigoto is almost the same as that in other areas of Japan, the incidence of gastric cancer in Kamigoto is lower. This study examined whether HTLV-1 infection affects H. pylori infection and the developm...

Journal: :Antimicrobial agents and chemotherapy 2008
Emanuela Balestrieri Arianna Ascolani Yasuhiro Igarashi Toshikazu Oki Antonio Mastino Jan Balzarini Beatrice Macchi

Peripheral blood mononuclear cells (PBMCs) from healthy individuals can be infected by human T-lymphotropic virus type 1 (HTLV-1) upon cocultivation of the PBMCs with irradiated HTLV-1-transformed human MT-2 cells. This model system closely mimics HTLV-1 transmission through cell-to-cell contact. Carbohydrate-binding agents (CBAs) such as the alpha(1,3)/alpha(1,6)mannose-specific Hippeastrum hy...

Journal: :Japanese journal of cancer research : Gann 1990
D Nakayama S Katamine H Kanazawa N Shibuya K Kawase R Moriuchi T Miyamoto S Hino

We studied DNA sequences homologous to HTLV-1 in peripheral blood mononuclear cells (PBMC) of 30 patients with neurological disorders in Kyushu, where HTLV-1 is highly endemic. The regions of HTLV-1 amplified by means of polymerase chain reaction (PCR) included U3, U5, gag, pol, env and pX. Our system specifically detected HTLV-1 sequences only from HTLV-1-positive cells and was sufficiently se...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010
Gustavo Pompermaier Garlet Silvana Pereira Giozza Elcia Maria Silveira Marcela Claudino Silvane Braga Santos Mario Julio Avila-Campos Walter Martins Cristina Ribeiro Cardoso Ana Paula Favaro Trombone Ana Paula Campanelli Edgar Marcelino Carvalho João Santana Silva

BACKGROUND Periodontal diseases (PDs) are infectious diseases in which periodontopathogens trigger chronic inflammatory and immune responses that lead to tissue destruction. Recently, viruses have been implicated in the pathogenesis of PDs. Individuals infected with human T lymphotropic virus 1 (HTLV-1) present with abnormal oral health and a marked increased prevalence of periodontal disease. ...

2017
Yoshimi Enose-Akahata Ashley Vellucci Steven Jacobson

Human T cell lymphotropic virus type 1 (HTLV-1) infection can lead to development of adult T cell leukemia/lymphoma (ATL) or HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a subset of infected subjects. Understanding the interaction between host and HTLV-1 and the molecular mechanisms associated with disease pathogenesis is critical for development efficient therapies. T...

Journal: :The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 2005
Jaqueline B Guerreiro Maria Aurélia F Porto Silvane B Santos Lino Lacerda John L Ho Edgar M Carvalho

Human T cell lymphotropic Virus type-1 (HTLV-1) induces lymphocyte activation and proliferation, but little is known about the innate immune response due to HTLV-1 infection. We evaluated the percentage of neutrophils that metabolize Nitroblue tetrazolium (NBT) to formazan in HTLV-1 infected subjects and the association between neutrophil activation and IFN-gamma and TNF-alpha levels. Blood was...

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