نتایج جستجو برای: hsv type 2

تعداد نتایج: 3463245  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Andrew H Karaba Sarah J Kopp Richard Longnecker

Infection with herpes simplex virus type 1 (HSV-1) and HSV-2 is initiated by viral glycoprotein D (gD) binding to a receptor on the host cell. Two receptors, herpesvirus entry mediator (HVEM) and nectin-1, mediate entry in murine models of HSV-1 and HSV-2. HVEM is dispensable for HSV-2 infection of the vagina and brain, but is required for WT pathogenesis of HSV-1 infection of the cornea. By ch...

2013
William P. Halford Joshua Geltz Edward Gershburg

We lack a correlate of immunity to herpes simplex virus 2 (HSV-2) that may be used to differentiate whether a HSV-2 vaccine elicits robust or anemic protection against genital herpes. This gap in knowledge is often attributed to a failure to measure the correct component of the adaptive immune response to HSV-2. However, efforts to identify a correlate of immunity have focused on subunit vaccin...

Journal: :BMC Infectious Diseases 2004
Dominique Bünzli Vincent Wietlisbach Fabrizio Barazzoni Roland Sahli Pascal RA Meylan

BACKGROUND Genital herpes is one of the most prevalent sexually-transmitted diseases, and accounts for a substantial morbidity. Genital herpes puts newborns at risk for very severe disease and also increases the risk of horizontal HIV transmission. It thus stands as an important public health problem. The recent availability of type-specific gG-based assays detecting IgG against HSV-1 and HSV-2...

Journal: :Antimicrobial agents and chemotherapy 1991
E De Clercq A Holý

The phosphonylmethoxyalkyl derivative (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) was evaluated for its in vivo efficacy in several model infections for herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) and thymidine kinase-deficient (TK-) HSV-1 in mice. In hairless mice infected intracutaneously with HSV-1 or HSV-2, HPMPC completely suppressed all manifestations of the dis...

2015
Meghna Ramaswamy V. N. Ramaswamy

Genital infection with herpes simplex virus type 2 (HSV -2) is increasingly common worldwide. The aims of this thesis were to investigate the epidemiology and natural history of genital herpes among GUM attendees with symptomatic genital herpes, and among HIV-l infected individuals. In our study of GUM attendees in the UK, we demonstrated HSV -1 to account for 9% of first episodes of genital he...

Journal: :Antimicrobial agents and chemotherapy 1986
H Machida

The susceptibilities of varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) to 17 nucleoside analogs were compared by a plaque reduction assay with human embryonic lung fibroblast cells. The susceptibility of VZV to certain nucleoside analogs was different from that of HSV-1. Against VZV the 5-halogenovinyl-arabinosyluracils were the most potent of the compou...

Journal: :American journal of epidemiology 2011
Brooke E Hoots Michael G Hudgens Stephen R Cole Caroline C King Robert S Klein Kenneth H Mayer Anne M Rompalo Jack D Sobel Denise J Jamieson Jennifer S Smith

Many studies have chronicled the "epidemiologic synergy" between human immunodeficiency virus (HIV) and herpes simplex virus type 2 (HSV-2). HIV adversely affects the natural history of HSV-2 and results in more frequent and severe HSV-2 reactivation. Few longitudinal studies, however, have examined whether HSV-2 is associated with increased HIV plasma viral loads or decreased CD4 counts. The a...

Journal: :The Journal of infectious diseases 2010
Sunitha Tata Christine Johnston Meei-Li Huang Stacy Selke Amalia Magaret Lawrence Corey Anna Wald

BACKGROUND Genital shedding of herpes simplex virus (HSV) type 2 occurs frequently. Anatomic patterns of genital HSV-2 reactivation have not been intensively studied. METHODS Four HSV-2-seropositive women with symptomatic genital herpes attended a clinic daily during a 30-day period. Daily samples were collected from 7 separate genital sites. Swab samples were assayed for HSV DNA by quantitat...

Journal: :Scientific reports 2016
Ji Eun Oh Myeong Sup Lee Young-Joon Kim Heung Kyu Lee

Type I interferon (IFN) interferes with virus replication, promotes antiviral responses, and controls innate and adaptive immune responses to certain viruses. Recently, we reported that 2'-5' oligoadenylate synthetase-like 1 (OASL1) negatively regulates type I IFN production by inhibiting the translation of the type I IFN-regulating master transcription factor, IRF7. Notably, while OASL1-defici...

Journal: :The Journal of infectious diseases 2014
Briana Nixon Esra Fakioglu Martha Stefanidou Yanhua Wang Monica Dutta Harris Goldstein Betsy C Herold

BACKGROUND Epidemiological studies consistently demonstrate synergy between herpes simplex virus type 2 (HSV-2) and human immunodeficiency virus type 1 (HIV-1). Higher HIV-1 loads are observed in coinfected individuals, and conversely, HIV-1 is associated with more-severe herpetic disease. A small animal model of coinfection would facilitate identification of the biological mechanisms underlyin...

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