نتایج جستجو برای: hr roles

تعداد نتایج: 251621  

2016
Bandhan Mukherjee Qi Yuan

The interactions of L-type calcium channels (LTCCs) and NMDA receptors (NMDARs) in memories are poorly understood. Here we investigated the specific roles of anterior piriform cortex (aPC) LTCCs and NMDARs in early odor preference memory in mice. Using calcium imaging in aPC slices, LTCC activation was shown to be dependent on NMDAR activation. Either D-APV (NMDAR antagonist) or nifedipine (LTC...

Journal: :Development 2005
Yoriko Nakamura Kazuhiro W Makabe Hiroki Nishida

Maternal mRNAs localized to specific regions in eggs play important roles in the establishment of embryonic axes and germ layers in various species. Type I postplasmic/PEM mRNAs, which are localized to the posterior-vegetal cortex (PVC) of fertilized ascidian eggs, such as the muscle determinant macho-1 mRNA, play key roles in embryonic development. In the present study, we analyzed the functio...

Journal: :The American journal of physiology 1998
Jonas Spaak Patrik Sundblad Dag Linnarsson

Our aim was to determine the roles of somatomotor activation and muscle ischemia for the tachycardia and hypertension of isometric arm contraction. Carotid-cardiac and carotid-mean arterial pressure (MAP) baroreflex response curves were determined in 10 men during rest, during isometric arm contraction at 30% of maximum, and during postcontraction ischemia. Carotid distending pressure (CDP) was...

2016
Tae Ju Park Yang Hyun Cho Ho Seok Chung Eu Chang Hwang Sung-Hoon Jung Jun Eul Hwang Woo Kyun Bae Jin Woong Kim Suk Hee Heo Young Hoe Hur Seung Il Jung Dong Deuk Kwon

BACKGROUND The platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) have been reported as prognostic factors in various cancers, but their roles in metastatic renal cell cancer (mRCC) remain unclear. We investigated the significance of PLR and NLR, along with that of established prognostic factors, in mRCC patients receiving first-line tyrosine kinase inhibitors (TKI). METHOD...

Journal: :Journal of neuroscience research 2015
Johanna L Hannan Maarten Albersen Bernard L Stopak Xiaopu Liu Arthur L Burnett Ahmet Hoke Trinity J Bivalacqua

Despite nerve-sparing radical prostatectomy, nerve damage and erectile dysfunction (ED) prevail, and preventing neurodegeneration is of great importance. Neurotrophic factors and neurite outgrowth were characterized in major pelvic ganglia (MPG) following bilateral cavernous nerve injury (BCNI). Young male Sprague-Dawley rats underwent sham or BCNI surgery, and the intracavernosal pressure to m...

Journal: :Plant physiology 2015
Guan-Feng Wang Yijian He Renee Strauch Bode A Olukolu Dahlia Nielsen Xu Li Peter J Balint-Kurti

In plants, most disease resistance genes encode nucleotide binding Leu-rich repeat (NLR) proteins that trigger a rapid localized cell death called a hypersensitive response (HR) upon pathogen recognition. The maize (Zea mays) NLR protein Rp1-D21 derives from an intragenic recombination between two NLRs, Rp1-D and Rp1-dp2, and confers an autoactive HR in the absence of pathogen infection. From a...

Journal: :Vezetéstudomány / Budapest Management Review 2009

Journal: :Evidence-based HRM: a Global Forum for Empirical Scholarship 2018

2015
Laura Nelson Hayley D. McKeen Andrea Marshall Laoighse Mulrane Jane Starczynski Sarah J. Storr Fiona Lanigan Christopher Byrne Ken Arthur Shauna Hegarty Ahlam Abdunnabi Ali Fiona Furlong Helen O. McCarthy Ian O. Ellis Andrew R. Green Emad Rakha Leonie Young Ian Kunkler Jeremy Thomas Wilma Jack David Cameron Karin Jirström Anita Yakkundi Lana McClements Stewart G. Martin William M. Gallagher Janet Dunn John Bartlett Darran O’Connor Tracy Robson

FK506-binding protein-like (FKBPL) has established roles as an anti-tumor protein, with a therapeutic peptide based on this protein, ALM201, shortly entering phase I/II clinical trials. Here, we evaluated FKBPL's prognostic ability in primary breast cancer tissue, represented on tissue microarrays (TMA) from 3277 women recruited into five independent retrospective studies, using immunohistochem...

Journal: :Biochemical Society transactions 2009
Dennis W Grogan

HR (homologous recombination) is expected to play important roles in the molecular biology and genetics of archaea, but, so far, few functional properties of archaeal HR have been measured in vivo. In the extreme thermoacidophile Sulfolobus acidocaldarius, a conjugational mechanism of DNA transfer enables quantitative analysis of HR between chromosomal markers. Early studies of this system indi...

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