Chronic uraemia is associated with severe disturbances in the calcium, phosphorus and vitamin D homeostasis, leading to the development of secondary hyperparathyroidism (HPT) with increased biosynthesis and secretion of parathyroid hormone (PTH) and hyperplasia of the parathyroid glands. Renal osteodystrophy (ROD) is a frequent and serious complication in chronic uraemic patients, which in a ma...

Abstract. A multi-body dynamical model of a wind turbine power generation system (WTPGS) based on hydromechanical hybrid transmission (HMHPT) technology is developed and simulated to overcome the individual drawbacks gear train hydrostatic (HPT) system. The HMHPT concept single-stage planetary (SSPGT) typical HPT. input shaft SSPGT coupled with rotor, whereas output hydraulic pump. pump supplie...

Calcitriol treatment is used to reduce parathyroid hormone levels in azotemic patients with secondary hyperparathyroidism (HPT). Whether long-term calcitriol administration reduces parathyroid gland size in patients with severe secondary hyperparathyroidism is not clear. The aim of the study was to evaluate in vitro the effect of calcitriol on parathyroid cell proliferation and apoptosis in nor...

INTRODUCTION Cinacalcet is effective in reducing serum parathyroid hormone (PTH) in patients with secondary hyperparathyroidism (HPT). This study focused on testing whether a prescription of low-dose cinacalcet on alternate days could be an option for treatment of secondary HPT. MATERIALS AND METHODS A retrospective clinical study was conducted on chronic maintenance hemodialysis patients. Pa...

In this study, the influence of high-pressure torsion (HPT) processing parameters and solution treatment (ST) on corrosion tribocorrosion behavior CoCrMo (CCM) alloys was investigated for possible usage in biomedical applications. The CCM by using potentiodynamic scanning (PDS) electrochemical impedance spectroscopy (EIS) tests. Tribocorrosion tests were carried out a reciprocating ball-on-plat...

Abstract Experiments were conducted to investigate, within the framework of a multiscale approach, mechanical enhancement, deformation and damage behavior copper–silicon carbide composites (Cu–SiC) fabricated by spark plasma sintering (SPS) combination SPS with high-pressure torsion (HPT). The properties metal–matrix determined at three different length scales corresponding macroscopic, micro- ...

Besides the well-known function of thyroid hormones (THs) for regulating metabolism, it has recently been discovered that THs are also involved in testicular development in mammalian and non-mammalian species. THs, in combination with follicle stimulating hormone, lead to androgen synthesis in Danio rerio, which results in the onset of spermatogenesis in the testis, potentially relating the hyp...

Efficient replication in vivo is essential for a microparasite to colonize its host and the understanding of the molecular mechanisms by which microbial pathogens grow within host tissues can lead to the discovery of novel therapies to treat infection. Here we present evidence that the foodborne bacterial pathogen Listeria monocytogenes, a facultative intracellular parasite, exploits hexose pho...

The nephrotoxic metabolite of the environmental contaminant trichloroethylene, S-(1,2-dichlorovinyl)-l-cysteine (DCVC), is known to elicit cytotoxicity in rat and human proximal tubular (rPT and hPT, respectively) cells that involves inhibition of mitochondrial function. DCVC produces a range of cytotoxic and compensatory responses in hPT cells, depending on dose and exposure time, including ne...

INTRODUCTION White Structure Flaking (WSF) is a type of surface damage responsible for some early failures in wind turbine gearbox bearings. WSF has been associated with microstructural changes registered close to the damaged surface that appear to be white after etching, hence the name White Etching Areas (WEAs). Local hydrogen liberation from lubricants [2] and adiabatic shear bands [3] have...