This research aimed to investigate effects of dough improvers (trehalose; TR, sucrose ester; SE and hydroxylpropylmethylcellulose; HPMC) on microstructural, textural, rheological and baking properties of frozen dough with virgin coconut oil using central composite design (CCD). Frozen dough containing dough improvers had higher values of all properties compared to frozen dough without dough imp...

A colon-specific capsule with alginate beads containing a self-microemulsifying drug delivery system (SMEDDS) was developed and evaluated. The SMEDDS technique was used to improve the solubility of curcumin (Cur). After encapsulating the Cur-loaded SMEDDS, the alginate beads were placed inside an impermeable capsule body. A konjac glucomannan/lactose/hydroxypropyl methylcellulose (KG/Lac/ HPMC)...

The purpose of this investigation was to prepare a gastro retentive drug delivery system of famotidine tablets. Floating tablets of famotidine were prepared employing lipid solid dispersion spray drying technique with gelucire 50/13 and compritol 888 along with HPMC K100M, lactose, sodium bicarbonate and citric acid. The floating tablets were evaluated for uniformity of weight, hardness, friabi...

The aim of this work was to investigate the effects of the nature and concentration of cellulose derivatives on the release kinetics of ibuprofen from hydrogel matrices using a response surface method (RSM). A series of cellulose derivatives, as methyl, hydroxyethyl, hydroxypropyl and hydroxypropyl methyl celluloses (MC, HEC, HPC and HPMC) were used as polymer platforms and their impacts on dru...

The corrosion inhibition characteristics of the derivatives of biopolymer hydroxypropyl methylcellulose (HPMC), hydroxypropyl methylcellulose phthalate (HPMCP), and hydroxypropyl methylcellulose acetate succinate (HPMCAS) film are investigated. Based on electrochemical impedance spectroscopic measurements and potentiodynamic polarization, the corrosion inhibition performance of high speed steel...

Itraconazole is practically insoluble in water; large interindividual and intra-individual variations of its oral bioavailability are reported. The main purpose of this study was to prepare and evaluate itraconazole granules for immediate release as drug delivery formulations. As a part of formulation optimization, different concentrations of hydroxypropyl-methyl cellulose (HPMC) E5 were taken ...

Ketoprofen is a potent non-steroidal anti-inflammatory drug which is used for the treatment of rheumatoid arthritis. The oral administration of ketoprofen can cause gastric irritation and renal adverse effects. Topical application of the drug can bypass gastrointestinal disturbances and provide relatively consistent drug levels at the site of action. Since the efficacy of gels depends on the ty...

The objective of this study was to develop controlled release matrix embedded formulations of celecoxib (CCX) as candidate drug using hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose (EC), either alone or in combination, using optimization techniques like polynomial method and composite design. This would enable development of controlled release formulations with predictable and bette...

OBJECTIVE To study the in vitro transdermal permeation of trimetazidine from hydroxypropylmethyl cellulose (HPMC) gel drug reservoir system using nerodilol as a penetration enhancer. MATERIALS AND METHODS An HPMC gel containing selected concentrations of nerodilol (0, 2, 4 or 5% w/v) and 2.5% w/v of trimetazidine was prepared, and subjected to in vitro permeation studies across rat epidermis....