LDPE remains the classic material of choice for many Extrusion Coating Applications, due to excellent processing and end-use performance reasons. High shear extrusion screws are desirable, actually promoting oxidation of the melt for improved adhesion to substrates. T-shaped flat die technology, with internal deckling, has emerged as the premium technology to handle monolayer and multilayer ext...

The objective of the present investigations was to assess use thermodynamic phase diagrams and Gibbs free energy mixing, ?Gmix, for screening polymeric carriers by determining ideal drug-loading an amorphous solid dispersion formulation optimum processing temperature hot-melt extrusion a non-glass-forming drug. Mefenamic acid (MFA) used as model drug four chemically distinct polymers with close...

Realgar (As4S4) has been demonstrated to be effective for the treatment of acute myeloid leukemia (AML); it has the advantages of no drug resistance and oral administration. Nevertheless, its poor solubility has been an obstacle to its bioavailability, requiring high-dose administration over a long period. We investigated whether crushing realgar crystals to the nanoscale and encapsulating the ...

The purpose of this study was to investigate the influence of sodium bicarbonate on the physicochemical properties of controlled release hot-melt extruded (HME) tablets containing Eudragit RS PO and/or Eudragit E PO. Acetohydroxamic acid and chlorpheniramine maleate were used as model drugs. Sodium bicarbonate was incorporated into the tablet formulations and the drug release properties and buo...

Hot melt extrusion (HME) is considered an efficient technique in developing solid molecular dispersions, and has been demonstrated to provide sustained, modified and targeted drug delivery resulting in improved bioavailability. However, most commercial enteric or pH-responsive polymers are relatively difficult to process or have high Glass Transition Temperature (Tg) values, making their use wi...

This work studied artemether (ARTM) solid dispersion (SD) formulation using mixture of polymer excipient Soluplus, PEG 400, Lutrol F127, and Lutrol F68 melts at temperatures lower than the melting point of ARTM using a laboratory-size, single-screw rotating batch extruder. The effects of three surfactants PEG 400, Lutrol F127, and Lutrol F68 and parameters like mixing temperature, screw rotatin...