Hot melt extrusion is one of the most popular techniques for manufacturing amorphous solid dispersions (ASDs). Over few decades, it has transitioned from lab scale to commercial with various products in market. The current review aims at summarizing considerations formulation development ASDs using HME. Various types Type I IV are discussed along state drug and polymeric carrier each type. Also...

Infectious disease outbreaks within healthcare facilities can exacerbate patient illness and, in some cases, be fatal. Contaminated surfaces and medical devices act as a reservoir for transmission of pathogens have been linked to the rising incidence healthcare-acquired infections. Antimicrobial reduce microbial contamination emerged crucial component infection control recent years. The aim thi...

Over the last three decades industrial adaptability has allowed hot-melt extrusion (HME) to gain wide acceptance and has already established its place in the broad spectrum of manufacturing operations and pharmaceutical research developments. HME has already been demonstrated as a robust, novel technique to make solid dispersions in order to provide time controlled, modified, extended, and targ...

Convective heat transfer about an isothermal, cylindrical extrudate of constant diameter, issuing continuously from an extrusion die, is investigated numerically, using a commercial CFD software package. The hot extrudate is assumed to move vertically downward, thus giving rise to a combined regime of forced and free convection in the surrounding fluid. Prandtl number of 0.707, corresponding to...

Deformation Behaviour of microcrystalline (mc) and nanocrystalline (nc) Mg-5%Al alloys produced by hot extrusion of ball-milled powders were investigated using instrumented indentation tests. The hardness values of the mc and nc metals exhibited indentation size effect (ISE), with nc alloys showing weaker ISE. The highly localized dislocation activities resulted in a small activation volume, he...

Isotactic polypropylenes (iPP) with different melt flow indexes (MFI) were used to fabricate nanocomposites (NCs) with 10 wt % loadings of multi-wall carbon nanotubes (MWCNTs) using ultrasound-assisted extrusion methods to determine their effect on the morphology, melt flow, and electrical properties of the NCs. Three different types of iPPs were used with MFIs of 2.5, 34 and 1200 g/10 min. Fou...