Background: Pneumococci have developed multiple strategies to infect the host. Results: PepO is ubiquitously expressed pneumococcal protein that interacts with host proteins and facilitates host cell invasion and evasion of innate immunity. Conclusion: PepO is a plasminogen and fibronectin binding pneumococcal invasin. Significance: Understanding the mechanism of pneumococcal interaction with h...

Pathogen-host protein-protein interaction systems examine the interactions between the protein repertoires of 2 distinct organisms. Some of these pathogen proteins interact with the host protein system and may manipulate it for their own advantages. In this work, we designed an R script by concatenating 2 functions called rowDM and rowCVmed to infer pathogen-host interaction using previously re...

Histoplasma capsulatum is the most prevalent cause of fungal respiratory disease. The disease extent and outcomes are the result of the complex interaction between the pathogen and a host's immune system. The focus of our paper consists in presenting the current knowledge regarding the multiple facets of the dynamic host-pathogen relationship in the context of the virulence arsenal displayed by...

Phytosanitary agencies conduct plant biosecurity activities, including early detection of potential introduction pathways, to improve control and eradication of pest and pathogen incursions. For such actions, analytical tools based on solid scientific knowledge regarding plant-pest or pathogen relationships for pest risk assessment are needed. Recent evidence indicating that closely related spe...

Mycobacterium tuberculosis is endowed with the ability to persist within its intracellular niche for years, often tilting the balance of the host–pathogen interaction in its favour. The host resists infection by releasing damaging free radicals, pushing the pathogen towards lysosomal degradation, releasing an arsenal of cytokines for triggering adaptive immunity and facilitating apoptosis for e...

in western countries there is a growing incidence in obesity, inflammatory bowel disease (ibd) and colorectal cancer (crc), which places an increasingly important burden on the health care system. in the current decade, changes in intestinal microflora (i.e., dysbiosis) are likely the result of environment factors such as food, lifestyle, and medications which have been shown in obesity and ibd...

No field of research has embraced and applied genomic technology more than the field of microbiology. Comparative analysis of nearly 300 microbial species has demonstrated that the microbial genome is a dynamic entity shaped by multiple forces. Microbial genomics has provided a foundation for a broad range of applications, from understanding basic biological processes, host-pathogen interaction...

General properties of the antagonistic biomolecular interactions between viruses and their hosts (exogenous interactions) remain poorly understood, and may differ significantly from known principles governing the cooperative interactions within the host (endogenous interactions). Systems biology approaches have been applied to study the combined interaction networks of virus and human proteins,...

The aftermath of influenza infection is determined by a complex set of host-pathogen interactions, where genomic variability on both viral and host sides influences the final outcome. Although there exists large body of literature describing influenza virus variability, only a very small fraction covers the issue of host variance. The goal of this review is to explore the variability of host ge...