We analyzed the frequency and regional distribution of cells with genetic abnormalities of chromosomes 1, 14, and 22 in meningiomas. This data was evaluated for correlation to the clinical outcome of the patients. Eight defined areas of each of 77 paraffin-embedded meningioma samples (59 grade I, 13 grade II, and 5 grade III) were analyzed by fluorescent in situ hybridization using bacterial ar...

background: alteration in peripheral blood lymphocytes (pbls) is usually investigated to provide an evidence of the host immune responses to tumor antigens. the tumor infiltrating nk cells interact most closely with the tumor cells and more accurately reflect tumor host interactions. objective: to analyze peripheral blood and tumor associated natural killer (nk) cells in patients with breast ca...

Effective delivery of nanomedicines to tumor tissues depends on both the tumor microenvironment and nanomedicine properties. Accordingly, tumor microenvironment modification or advanced design of nanomedicine was emerging to improve nanomedicine delivery to tumors. However, few studies have emphasized the necessity to optimize the tumor microenvironment and nanomedicine properties simultaneousl...

a numerical study of 3d electrokinetic flows through micromixers was performed. the micromixers considered here consisted of heterogeneous rectangular microchannels with prescribed patterns of zeta-potential at their walls. numerical simulation of electroosmotic flows within heterogeneous channels requires solution of the navier-stokes, ernest-plank and species concentration equations. it is kn...

All pharmaceutical companies are required to assess pharmacokinetic drug-drug interactions (DDIs) of new chemical entities (NCEs) and mathematical prediction helps to select the best NCE candidate with regard to adverse effects resulting from a DDI before any costly clinical studies. Most current models assume that the liver is a homogeneous organ where the majority of the metabolism occurs. Ho...

we report the case of a 54-year-old iranian man who presented with melena from three months prior to admission. esophagogastroduodenoscopy and colonoscopy were normal. double balloon enteroscopy showed a pedunculated tumor located in the jejunum. he underwent laparotomy and resection of a 9.5 cm tumor from the distal jejunum. histopathologic evaluation confirmed the diagnosis of an inflammatory...

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background: wilms' tumor is an emberyonal tumor arising from remnants of immature renal tissue. her2/neu is an onco-protein which mediates cellular proliferation, differentiation and survival. methods: in the current study, we analyzed her2/neu expression in 40 wilms' tumors. the clinico-demographic data of 40 patients with wilms' tumor were retrieved. immunohistochemical staining for her2/neu ...

the majority of osseous tumors of the hand are benign. the surgeon who evaluates and treats osseous tumors of the hand has to be familiar with limb anatomy, tumor biology, various presentations of the tumors and the range of treatment possibilities and their limitations. lesions in the hand more often present earlier in their course than those at other sites, just because they are more likely t...