نتایج جستجو برای: hnf4a

تعداد نتایج: 457  

2018
Lay Teng Ang Antson Kiat Yee Tan Matias I. Autio Su Hua Goh Siew Hua Choo Kian Leong Lee Jianmin Tan Bangfen Pan Jane Jia Hui Lee Jen Jen Lum Christina Ying Yan Lim Isabelle Kai Xin Yeo Chloe Jin Yee Wong Min Liu Jueween Ling Li Oh Cheryl Pei Lynn Chia Chet Hong Loh Angela Chen Qingfeng Chen Irving L. Weissman Kyle M. Loh Bing Lim

How are closely related lineages, including liver, pancreas, and intestines, diversified from a common endodermal origin? Here, we apply principles learned from developmental biology to rapidly reconstitute liver progenitors from human pluripotent stem cells (hPSCs). Mapping the formation of multiple endodermal lineages revealed how alternate endodermal fates (e.g., pancreas and intestines) are...

Journal: :Journal of Clinical Investigation 2021

The ability to adapt low-nutrient microenvironments is essential for tumor cell survival and progression in solid cancers, such as colorectal carcinoma (CRC). Signaling by the NF-κB transcription factor pathway associates with advanced disease stages shorter patients CRC. has been shown drive tumor-promoting inflammation, cancer survival, intestinal epithelial (IEC) dedifferentiation mouse mode...

Journal: :Cell stem cell 2016
Guangqi Song Martin Pacher Asha Balakrishnan Qinggong Yuan Hsin-Chieh Tsay Dakai Yang Julia Reetz Sabine Brandes Zhen Dai Brigitte M Pützer Marcos J Araúzo-Bravo Doris Steinemann Tom Luedde Robert F Schwabe Michael P Manns Hans R Schöler Axel Schambach Tobias Cantz Michael Ott Amar Deep Sharma

Direct induction of induced hepatocytes (iHeps) from fibroblasts holds potential as a strategy for regenerative medicine but until now has only been shown in culture settings. Here, we describe in vivo iHep formation using transcription factor induction and genetic fate tracing in mouse models of chronic liver disease. We show that ectopic expression of the transcription factors FOXA3, GATA4, H...

Journal: :Cell stem cell 2014
Yuanyuan Du Jinlin Wang Jun Jia Nan Song Chengang Xiang Jun Xu Zhiyuan Hou Xiaohua Su Bei Liu Tao Jiang Dongxin Zhao Yingli Sun Jian Shu Qingliang Guo Ming Yin Da Sun Shichun Lu Yan Shi Hongkui Deng

Obtaining fully functional cell types is a major challenge for drug discovery and regenerative medicine. Currently, a fundamental solution to this key problem is still lacking. Here, we show that functional human induced hepatocytes (hiHeps) can be generated from fibroblasts by overexpressing the hepatic fate conversion factors HNF1A, HNF4A, and HNF6 along with the maturation factors ATF5, PROX...

Journal: :Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 2018

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید