نتایج جستجو برای: hmg و r
تعداد نتایج: 1198316 فیلتر نتایج به سال:
Recent studies have shown that the administration of endotoxin (LPS) and cytokines to Syrian hamsters increases serum cholesterol levels, hepatic cholesterol synthesis, and the activity, protein levels, and mRNA levels of hepatic HMG-CoA reductase. Despite the greater than 10-fold increase in HMG-CoA reductase mRNA levels, LPS had only minimal effects on hepatic LDL receptor mRNA levels. In the...
چکیده استاتین ها با مهار آنزیم هیدروکسی متیل گلوتاریل کوانزیم آ ردوکتاز (hmg co a r)، از ساخت کلسترول جلوگیری کرده و منجر به کاهش غلظت خونی آن می شوند. شواهدی از خواص دیگر این داروها شامل خواص ضدالتهابی، آنتی اکسیدان و ضد لخته وجود دارد. اخیراً اثرات ضد استوپروز نیز به این خواص اضافه گردیده است. مصرف این داروها با عوارضی همراه می باشند که اختلالات روماتولوژیک مانند لوپوس و میوپاتی را تقلید می کن...
We previously reported that the chromatin high-mobility group protein 1 (HMG-1) enhances the sequence-specific DNA binding activity of progesterone receptor (PR) in vitro, thus providing the first evidence that HMG-1 may have a coregulatory role in steroid receptor-mediated gene transcription. Here we show that HMG-1 and the highly related HMG-2 stimulate DNA binding by other steroid receptors,...
This study analyses the influence of female and male patient age and human menopausal gonadotrophin (HMG) requirements on clinical pregnancy rates and live birth rates with ovulation stimulation using HMG in combination with intrauterine insemination (IUI). In this study, 363 consecutive HMG/IUI treatment cycles in 184 patients carried out at a university fertility centre were analysed in a ret...
Isoflavones identified as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in soybean paste were assayed using the catalytic portion of Syrian hamster HMG-CoA reductase, and the kinetic values were measured using HMG-CoA and NADPH. The inhibition of HMG-CoA reductase by these inhibitors was competitive with HMG-CoA and noncompetitive with NADPH. Ki values for genistein, d...
Face recognition is important in human identification. The biological recognition technique acts as a good method and broad applications in security areas. This work presents a method to improve the face recognition accuracy using a combination of Principal Component Analysis (PCA), and Wavelet Transform. Wavelet Transform is used to decompose the input image with different levels and rearrange...
Abstract Statins are a group of drugs that prevent cholesterol building and reduce its concentration in blood by inhibiting the hydroxymethylglutaryl-coenzyme A reductase (HMG CoA r). There are evidences showing other properties including anti-inflammatory, anti-oxidant and anti-thrombotic effects of these agents. Some anti-osteoporotic effects have recently been added to these properties. H...
Male breast cancer (MBC) is a rare hormone-driven disease often associated with obesity. HMG-CoAR is the central enzyme of the mevalonate pathway, a molecular route deputed to produce cholesterol and steroid-based hormones. HMG-CoAR regulates the oncogenic Hippo transducers TAZ/YAP whose expression was previously associated with shorter survival in MBC. 225 MBC samples were immunostained for HM...
The activity of microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) [mevalonate:NADP+ oxidoreductase (CoA-acylating); EC 1.1.1.34] was inhibited by ATP+Mg2+. Inactivation of HMG-CoA reductase by ATP+Mg2+ was dependent on time, temperature, and ATP concentration. Incubation of microsomal HMG-CoA reductase with [gamma-32P]ATP+Mg2+ was associated with a reciprocal increa...
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