The HMG-box is an approximately 75-amino acid residue protein domain that occurs in all eukaryotic organisms and was first identified as a characteristic feature of the chromosomal high mobility group (HMG) proteins of the HMGB type. Structural studies have demonstrated that the L-shaped fold of the domain formed by three a-helices is conserved to a greater extent than expected from amino acid ...

The quantitative changes of the high mobility group (HMG) nonhistone chromosomal proteins in nondividing, differentiated peritoneal exudate neutrophils were identified by their solubility, electrophoretic mobility on both SDS and acetic acid gels, densitometric traces and elution profile on CM-sephadex. The results indicated that in neutrophils, HMGl undergoes a considerable reduction (80%...

Microgrids with non-conventional energy sources have become popular recently. Hybrid AC-DC microgrid (HMG) architecture is effectual as it avoids several power conversions for the consumers. Therefore, this article presents a comprehensive study on grid-tied HMG PV array and wind conversion system (WECS) principal sources. Fuel cell (FC) acts auxiliary source in DC subgrid supercapacitor (SC) u...

Lymphatic drainage leads to a significant stimulation of both the cholesterol 7 alpha-hydroxylase and HMG-CoA reductase activity in rats (Björkhem et al. 1978. Biochem. Biophys. Res. Commun. 85: (532-540). This finding was confirmed here and it was also shown that ligation of the lymph duct leads to a similar but less pronounced effect. Ligation of the lymph duct or lymph fistulation of bile du...

The T-cell factor (TCF) family of transcription factors are major mediators of Wnt/β-catenin signaling in metazoans. All TCFs contain a High Mobility Group (HMG) domain that possesses specific DNA binding activity. In addition, many TCFs contain a second DNA binding domain, the C-clamp, which binds to DNA motifs referred to as Helper sites. While HMG and Helper sites are both important for the ...

Infection and inflammation increase serum triglyceride and cholesterol levels in rodents and rabbits. Endotoxin (LPS) has been used as a model of infection and its effects on triglyceride metabolism have been previously characterized. In the present study we demonstrate that both low (100 ng/100 g body weight) and high dose (100 micrograms/100 g body weight) LPS increase serum cholesterol level...

OBJECTIVE To evaluate the comparative efficacy and safety of the 4 currently available hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, fluvastatin, lovastatin, pravastatin, and simvastatin, in the treatment of primary hypercholesterolemia. DATA SOURCES English-language clinical studies, abstracts, and review articles identified from MEDLINE searches and bibliographies of iden...

The high mobility group (HMG) proteins are the major nonhistone components of chromatin (1). Among these, the HMG1 and HMG2 proteins are the most abundant; however, their precise function remains undefined. There are some indications for a putative role of HMG 1/2 in chromatin assembly (2), DNA replication (3) or even as general transcription factors for RNA polymerase II (4). There is a consid...

Chronic rhinosinusitis with nasal polyposis is considered to be a multifactorial disease where different stimuli (mechanical, viral, bacterial, fungal infection, immunological disorders or dysreactivity, environmental pollution), acting on the mucosa of nasal cavities and paranasal sinuses, lead to epithelial damage and mucosal inflammation. Inflammatory cell infiltration (predominantly eosinop...

Hydrogels have become popular as drug carriers. Controlled release of the drugs from hydrogels can reduce dosage, inducing prevention side effects. However, hydrophilicity interferes with controlled hydrophobic such anticancer agents or antibiotics. In this study, we developed hydrophobically-modified gelatin (HMG) hydrogel, which was cross-linked only by interaction. HMG does not require toxic...