نتایج جستجو برای: hla class i

تعداد نتایج: 1404625  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1996
M J Maeurer S M Gollin W J Storkus W Swaney J Karbach D Martin C Castelli R Salter A Knuth M T Lotze

Specific CD8(+) CTL recognition of melanoma requires expression of MHC class I molecules as well as melanoma-associated peptide epitopes. Human melanoma cells may escape immune recognition by a variety of means, including global or allelic down-regulation of MHC class I molecules. Stable MHC class I cell surface expression requires delivery of cytosolic peptides into the endoplasmic reticulum b...

Journal: :iranian journal of allergy, asthma and immunology 0
ehteramolsadat hosseini malignant hematology and stem cell transplantation service, alfred hospital, monash university, melbourne, australia anthony p. schwarer malignant hematology and stem cell transplantation service, alfred hospital, monash university, melbourne, australia mehran ghasemzadeh australian centre for blood diseases, monash university, melbourne, australia

the  non-classical mhc  class-i mainly involves in the  regulation of  innate  immune responses where hla-e  plays a significant role in the cell identification by natural killer cells. hla-e is a main regulatory ligand for natural killer cells and given the importance of these effector cells in hematopoietic stem cell transplantation, we investigated the effect of hla-e polymorphisms on post-h...

Journal: :Pediatrics 2013
Nisha Shah Ricardo Sorensen

BACKGROUND Recent studies have suggested that the birth order effect in allergy may be established during the prenatal period and that the protective effect may originate in the mother. HLA class II disparity between mother and foetus has been associated with significantly increased Th1 production. In this study, we investigated whether production of HLA antibodies 4 years after pregnancy with ...

2015
Yuji Iwayama Tetsuhiro Tsuruma Toru Mizuguchi Tomohisa Furuhata Nobuhiko Toyota Masayuki Matsumura Toshihiko Torigoe Noriyuki Sato Koichi Hirata

BACKGROUND Prognostic factors are useful for determination of the therapeutic strategy and follow-up examination after curative operation in cancer treatment. The immunological state of the host can influence the prognosis for cancer patients as well as the features of the cancer. Human lymphocyte antigen (HLA) class I molecules have a central role in the anti-cancer immune system. Therefore, w...

Journal: :Human immunology 2005
Christine F W Vermeulen Ekaterina S Jordanova Yvon A Zomerdijk-Nooijen Natalja T ter Haar Alexander A W Peters Gert Jan Fleuren

Loss at chromosome 6p21.3, the human leukocyte antigen (HLA) region, is the main cause of HLA downregulation, occurring in the majority of invasive cervical carcinomas. To identify the stage of tumor development at which HLA class I aberrations occur, we selected 12 patients with cervical carcinoma and adjacent cervical intraepithelial neoplasia (CIN). We investigated HLA class I and beta2-micr...

Journal: :Journal of immunology 2000
S A Desai X Wang E J Noronha Q Zhou V Rebmann H Grosse-Wilde F J Moy R Powers S Ferrone

The association of HLA class I heavy chains with beta2-microglobulin (beta2m) changes their antigenic profile. As a result, Abs react with either beta2m-free or beta2m-associated HLA class I heavy chains. An exception to this rule is the mAb TP25.99, which reacts with both beta2m-associated and beta2m-free HLA class I heavy chains. The reactivity with beta2m-associated HLA class I heavy chains ...

Journal: :The Journal of the Association of Physicians of India 2003
D N Amarapurkar N D Patel Anjali D Amarapurkar S R Kankonkar

OBJECTIVES To analyze association of different HLA genotypes for predisposition to type-I autoimmune hepatitis in Western India. METHODS This study was undertaken on patients of type-I autoimmune hepatitis (defined by international criteria by IAHG, 1999). HLA genotyping for class I and II was done in 20 patients of autoimmune hepatitis and 100 healthy controls. Statistics were done using Hal...

2017
Marcel Nijland Rianne N. Veenstra Lydia Visser Chuanhui Xu Kushi Kushekhar Gustaaf W. van Imhoff Philip M. Kluin Anke van den Berg Arjan Diepstra

Antigen presentation by tumor cells in the context of Human Leukocyte Antigen (HLA) is generally considered to be a prerequisite for effective immune checkpoint inhibitor therapy. We evaluated cell surface HLA class I, HLA class II and cytoplasmic HLA-DM staining by immunohistochemistry (IHC) in 389 classical Hodgkin lymphomas (cHL), 22 nodular lymphocyte predominant Hodgkin lymphomas (NLPHL), ...

Journal: :Journal of immunology 2002
Yi-Ping Jin Ram Pyare Singh Ze-Ying Du Ayyappan K Rajasekaran Enrique Rozengurt Elaine F Reed

The development of chronic rejection is the major limitation to long-term allograft survival. HLA class I Ags have been implicated to play a role in this process because ligation of class I molecules by anti-HLA Abs stimulates smooth muscle cell and endothelial cell proliferation. In this study, we show that ligation of HLA class I molecules on the surface of human aortic endothelial cells stim...

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