نتایج جستجو برای: hiv 1 dna vaccine
تعداد نتایج: 3346593 فیلتر نتایج به سال:
Induction of broadly cross-reactive antiviral humoral responses with the capacity to target globally diverse circulating strains is a key goal for HIV-1 immunogen design. A major gap in the field is the identification of diverse HIV-1 envelope antigens to evaluate vaccine regimens for binding antibody breadth. In this study, we define unique antigen panels to map HIV-1 vaccine-elicited antibody...
The genetic diversity among globally circulating human immunodeficiency virus type 1 (HIV-1) strains is a serious challenge for HIV-1 vaccine design. We have generated a synthetic group M consensus env gene (CON6) for induction of cross-subtype immune responses and report here a comparative study of T-cell responses to this and natural strain env immunogens in a murine model. Three different st...
uch can be asked of an AIDS vaccine. Ideally, vaccination would pre-empt the initial viremia associated with HIV infection, preventing illness, transmission, and the establishment of long-term viral reservoirs. If this goal of "sterilizing immunity" is not attainable, the vaccine-induced immune response would at least mitigate the effects of HIV infection by limiting viral replication. An optim...
T cell-mediated immune responses play an important role in the containment of HIV-1 replication. Therefore, an effective vaccine against HIV-1 should be able to elicit high frequencies of virus-specific CD8(+) and CD4(+) T cells. The highly attenuated poxvirus-based vaccine candidate, NYVAC-SIV-gag-pol-env (NYVAC-SIV-gpe), has been shown to induce and/or expand SIV-specific CD4(+) and CD8(+) T ...
BACKGROUND Observational data and non-human primate challenge studies suggest that cell-mediated immune responses might provide control of HIV replication. The Step Study directly assessed the efficacy of a cell-mediated immunity vaccine to protect against HIV-1 infection or change in early plasma HIV-1 levels. METHODS We undertook a double-blind, phase II, test-of-concept study at 34 sites i...
background: hepatitis c (hcv) is a worldwide problem without an effective vaccine with more than 170 million chronically infected people worldwide. dna vaccines expressing antigenic portions of the virus with adjutants have recently been developed as a novel vaccination technology. objectives: in the present study, a dna vaccine expressing hcv core protein was developed with il12 as a genetic a...
We tested the hypothesis that therapeutic vaccination against HIV-1 can increase the frequency and suppressive function of regulatory, CD4(+) T cells (Treg), thereby masking enhancement of HIV-1-specific CD8(+) T cell response. HIV-1-infected subjects on antiretroviral therapy (N = 17) enrolled in a phase I therapeutic vaccine trial received 2 doses of autologous dendritic cells (DC) loaded wit...
Cytotoxic T cell responses are key to the control of intracellular pathogens including HIV-1. In particular, HIV-1 vaccines based on regulatory proteins, such as Tat, are aimed at controlling HIV-1 replication and at blocking disease development by inducing cytotoxic T cell responses. Naked DNA is capable of inducing such responses but it requires several inoculations of high amounts of DNA, an...
A broadly effective HIV-1 vaccine would greatly contribute towards pathway deepens our understanding of the level of somatic prevention of the 2.1 million new HIV-1 infections estimated to occur annually. Six HIV-1 vaccine efficacy trials in humans have thus far been conducted. Whereas most vaccines showed no efficacy in preventing from HIV-1 infection – and two actually increased infection rat...
Despite considerable experience with single-dose, live, oral cholera vaccine CVD 103-HgR in Asia, Europe, and the Americas, the vaccine had not been evaluated in sub-Saharan Africa or on individuals infected with human immunodeficiency virus (HIV). We therefore conducted a randomized, placebo-controlled, double-blind, cross-over clinical trial in 38 HIV-seropositive (without clinical acquired i...
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