the forging model for cold rolling is one of rolling models that is used in rolling calculations. in this model,the final rolling pressure is an average value and it is not an accurate model.also by using this model,the firction hill curves are plotted due to the central point of the rolling bite length while frictional stresses intersect at the neutral point.in this study, a new model based on...

a nonlocal beam model based on the bernoulli–euler beam theory is presented to investigate the dynamic stability of embedded single-walled carbon nanotubes (swcnts) in thermal environment under combined static and periodic axial loads. the dynamic stability analysis is carried out by including the effects of small-scale parameter, temperature change and elastic medium. the equation of motion is...

(+/-) SKF83959, like many other arylbenzazepines, elicits powerful neuroprotection in vitro and in vivo. The neuroprotective action of the compound was found to partially depend on its D(1)-like dopamine receptor agonistic activity. The precise mechanism for the (+/-) SKF83959-mediated neuroprotection remains elusive. We report here that (+/-) SKF83959 is a potent blocker for delayed rectifier ...

beta-estradiol 17-(beta-D-glucuronide) (E217G) is a well known cholestatic agent and substrate of multidrug resistance-associated protein 2 (Mrp2), whereas beta-estradiol 3-(beta-D-glucuronide) (E23G) is a noncholestatic regioisomer of E217G with unknown transport properties. The purpose of this study was to compare and contrast the Mrp2-mediated transport of E217G and E23G. The full coding reg...

We have previously reported the existence of at least four troponin T isoforms in rabbit ventricular muscle and described the changes in their distribution with development. In this report we test whether the proportions of the troponin T isoforms are related to the sensitivity of the myofilaments to calcium. We measured the force-pCa relations in 12 detergent-skinned ventricular strands of car...

Puerarin is the main isoflavone found in Pueraria lobata (Willd) Ohwi, which has been used in therapy for various cardiovascular diseases. The present study examined the effects of puerarin on the large-conductance voltage- and Ca2+-activated potassium (BK(Ca)) channel and on rat thoracic aortas. BK(Ca) channels encoded with either alpha (BK-alpha) or alpha/beta subunits (BK-alpha+beta1) were h...

which the substrate kinase is converted to its active A recent meeting in Spain discussed the most important form will vary as the square of the activity of the upcell divisions in your life: the meioses that produced the stream kinase. Combining two such steps in succession egg and sperm that fused to create you. Most of the produces a cascade in which the activity of MAP kinase talks at the m...

Part of the neurotoxic effects of inorganic mercury (Hg(2+)) and methylmercury (MeHg) was attributed to their interaction with voltage-activated calcium channels. Effects of mercury on T-type calcium channels are controversial. Therefore, we investigated effects of Hg(2+) and MeHg on neuronal Ca(v)3.1 (T-type) calcium channel stably expressed in the human embryonic kidney (HEK) 293 cell line. H...

To determine features of the steady state [Ca2+]-tension relationship in intact heart, we measured steady force and intracellular [Ca2+] ([Ca2+]i) in tetanized ferret papillary muscles. [Ca2+]i was estimated from the luminescence emitted by muscles that had been microinjected with aequorin, a Ca2+-sensitive, bioluminescent protein. We found that by raising extracellular [Ca2+] and/or by exposin...

In this paper, we propose a locomotion training framework where control policy and state estimator are trained concurrently. The consists of network which outputs the desired joint positions estimation estimates robot's states such as base linear velocity, foot height, contact probability. We exploit fast simulation environment to train networks transferred real robot. capable traversing divers...