The glucose-dependency of cholecystokinin-8 (CCK-8)-stimulated insulin release was investigated at high (11.1 and 16.7 mM) glucose concentrations in rat pancreas perfusion and islet perifusion using glucose analogues, pseudo-alpha-D-glucose and 2-deoxy-D-glucose. In perfused pancreas, both glucose analogues (22.4 mM) inhibited high glucose (16.7 mM)-induced insulin release, but not normal gluco...

McGinn, S., P. Poronnik, M. King, E. D. M. Gallery, and C. A. Pollock. High glucose and endothelial cell growth: novel effects independent of autocrine TGF1 and hyperosmolarity. Am J Physiol Cell Physiol 284: C1374–C1386, 2003.FirstpublishedJanuary22,2003;10.1152/ajpcell.00466. 2002.—Human endothelial cells were exposed to 5 mM glucose (control), 25 mM (high) glucose, or osmotic control for 72 ...

Background: Prediabetes is a metabolic condition which is characterized by the presence of higher levels of blood glucose. It can be treated by lowering high blood glucose level and maintaining the healthy lifestyle habits, healthy meal plan and regular exercise. The aim of this study was to evaluate the prevalence of prediabetes and to identify the risk factors involved in its progression. Ma...

Background and Aims: Due to the high prevalence of carbohydrate and lipid metabolism disorders worldwide and in Iran and as recommended by the international diabetes federation, about more investment in diabetes research in Iran, it is decided to perform of this study in the urban and rural area of Gotvad city in the Khuzestan Province of Iran. Materials and Methods: In this cross-sectional st...

Introduction: Diabetes is one of the most common endocrine diseases. With regard to the importance of blood glucose regulation in prevention of diabetic complications, glycemic and insulinemic response determination of foods containing carbohydrates is greatly important. The purpose of the present study, therefore, was to determine the effect of low glycemic index foods taken at dinner on fasti...

abstract objective: diabetes mellitus is the most common metabolic disease. one of the most common problems in diabetic patients is atherosclerotic cardiovascular disease which is induced by hyperlipidemia. impaired lipid metabolism resulting from uncontrolled hyperglycemia has been implicated in cardiovascular complications in diabetic patients. also, glycated hemoglobin (hba1c) has been regar...