نتایج جستجو برای: high dose interferon
تعداد نتایج: 2344472 فیلتر نتایج به سال:
In 2011, the U.S. Food and Drug Administration (FDA) approved peginterferon-alfa-2b (Sylatron ; Merck/ScheringPlough, Kenilworth, NJ) for the adjuvant treatment of patients with resected node-positive melanoma based on the results of a single, large European Organization for Research and Treatment of Cancer (EORTC) trial showing a statistically significant improvement in the relapse-free surviv...
PHARMACOLOGY AND TOXICOLOGY T HE PHARMACOLOGY of interferons has been studied with human leukocyte interferon and with mouse and rabbit interferons. These have a short half-life in the blood, irrespective of the route of administration, though the most rapid clearance follows the intravenous route; intramuscular injections result in peak blood levels after 2-4 hr, lasting for 4-6 hr. With intra...
BACKGROUND The standard of care for HCV Hepatitis is the combination of interferon (IFN) plus Ribavirin. In HIV patients the use of this combination therapy may induce drug interactions, and reduces the adherence to HAART. The aim of this study is to evaluate safety and efficacy of a 48 weeks daily dose IFN schedule. METHODS We evaluated 50 coinfected patients; alpha IFN 2a was administered a...
1 Antoniou KM, Ferdoutsis E, Bouros D. Interferons and their application in the diseases of the lung. Chest 2003; 123:209–216 2 Interferonin the idiopathic hypereosinophilic syndrome: consideration of five cases. Ann Hematol 1998; 77:161–164 3 Baratta L, Afeltra A, Delfino M, et al. Favorable response to high-dose interferonin idiopathic hypereosinophilic syndrome with restrictive cardiomyopath...
BACKGROUND There is some controversy concerning the efficacy of low dose alpha interferon therapy in chronic hepatitis C. AIMS To evaluate the effectiveness of treatment with low doses of alpha interferon in chronic hepatitis C. PATIENTS One hundred and forty one patients with anti-HCV positive chronic active hepatitis C from six hospitals were enrolled in the study. METHODS Patients were...
BACKGROUND Alemtuzumab, a humanized monoclonal antibody that targets CD52 on lymphocytes and monocytes, may be an effective treatment for early multiple sclerosis. METHODS In this phase 2, randomized, blinded trial involving previously untreated, early, relapsing-remitting multiple sclerosis, we assigned 334 patients with scores of 3.0 or less on the Expanded Disability Status Scale and a dis...
Interferon therapy of hepatitis C causes a decrease in neutrophil counts, and neutropenia is a common reason for dose adjustment or early discontinuation. However, it is unclear whether neutropenia caused by interferon is associated with an increased rate of infection. In this study, we assessed factors associated and clinical consequences of neutropenia before and during interferon therapy of ...
Bamboo salt and egg white-chalcanthite mixture has been prescribed for relieving the inflammation of atopic dermatitis in Hamyang, Gyeongsangnam-do, Korea. This study was conducted to demonstrate effect on cell animal models using a combination bamboo with white-chalcanthite, which have used as folk remedies inflammatory conditions. Based vitro experiment, 1:20 shown inhibit release beta-hexosa...
None of the approved immunomodulatory drugs in adults Multiple Sclerosis (MS) patients have been officially approved for the pediatric patients and are currently used off-label in this population. In this study, we evaluated the effectiveness and tolerability of intramuscular interferon beta1-a (Avonex(®)) and subcutaneously injected interferon beta1-b (Betaferon(®)) in children with definite r...
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