نتایج جستجو برای: hexosaminidase activity
تعداد نتایج: 1134871 فیلتر نتایج به سال:
Biological functions of mast cells include a functional role in innate immunity against parasitic infections. Here, we demonstrated that mast cells could also play a role in the anti-microbial defenses regulation and might participate as a parasite reservoir. We observed that Toxoplasma gondii infected massively in vitro mouse bone marrow derived mast cells (BMMC), a mucosal mast cell (MMC) phe...
We have generated mouse models of human Tay-Sachs and Sandhoff diseases by targeted disruption of the Hexa (alpha subunit) or Hexb (beta subunit) genes, respectively, encoding lysosomal beta-hexosaminidase A (structure, alpha) and B (structure, beta beta). Both mutant mice accumulate GM2 ganglioside in brain, much more so in Hexb -/- mice, and the latter also accumulate glycolipid GA2. Hexa -/-...
An assay for measuring hexosaminidase A in serum and leucocytes is described in which a centrifugal analyser is used for automation of the enzyme assays after manual heat inactivation. The assay was used in a screening programme to identify heterozygotes for Tay-Sachs disease in Ashkenazi Jewish subjects in the UK. The first results from this programme indicate a carrier frequency of 1 in 27. A...
Abstraet--N-Acetyl-hexosaminidase (Hex) exists in various human tissues in two major isozymic forms--Hex A and Hex B. The main difference between the two forms is the lability of Hex A to both heat and acid as compared to the stability of Hex B. When heated to 50°C for 2-3 hr Hex A loses its entire enzymatic activity. In the present study we demonstrate that specific antiserum stabilizes Hex A ...
BACKGROUND The effect of multiple infusions of infliximab (INF), a chimeric anti-tumor necrosis factor alpha antibody, on the concentration of hexosaminidase (HEX) activity in a synovial cell culture derived from human synovial inflamed fluid obtained from patients suffering from rheumatoid arthritis (RA) has been evaluated. OBJECTIVES The aim of this study was to prove INF efficacy in RA. ...
Allergic rhinitis (AR) is the chronic type of that arises due to hypersensitivity response. It caused by nasal mucosa inflammation and becomes a social burden in later stages. Ponicidin diterpenoid isolated from herbs like Rabdosia rubescens possesses anti-inflammatory properties. Hence, present study was designed analyze effects against AR using ovalbumin (OVA)-sensitized murine model also rev...
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