Multicomponent reactions (MCRs) are extremely popular owing to their facile execution, high atom-efficiency and the high diversity of products. MCRs can be used to access various heterocycles and highly functionalized scaffolds, and thus have been invaluable tools in total synthesis, drug discovery and bioconjugation. Traditional isocyanide-based MCRs utilize an external nucleophile attacking t...

Since past few decades, certain heterocyclic scaffolds have drawn special attention of medicinal chemists due to their biological potential and hence extensive efforts are being undertaken to search potential lead molecules through their design and synthesis. Heterocycles have also been actively involved to treat many neurodenegerative disorders, including Alzheimer’s disease, Parkinsonism and ...

N-heterocycles, both saturated and unsaturated, are ubiquitous biologically active molecules that extremely appealing scaffolds in drug discovery programs. Although classical synthetic methods have been developed to access many relevant N-heterocyclic scaffolds, representing well-established reliable routes, some do not meet the needs of sustainability. In this context, several advances made to...