A polynucleating oxygen donor ligand based on condensation of p-chlorophenylstibonic acid (ArSbO(3)H(2)) and t-butylphosphonic acid is reported. [(SbAr)(2)O(HO(3)P(t)Bu)(6)] contains two antimony centres, bridged by an oxide and two hydrogen phosphonates. Reaction with copper acetate under solvothermal conditions produces four new polymetallic copper complexes. With pyridine used as a base the ...

Summal"y To determine the functional role of the two isoforms of Fc3,RIII (CD16) (IliA, IIIB), the signal transduction capabilities of wild-type and mutant forms of these receptors were analyzed in transfected lymphoid, myeloid, and fibroblastic cell lines. Functional reconstitution of receptor signalling was observed in hematopoietic T and mast cells, and was absent in nonhematopoietic (CHO) c...

A main challenge for structural biologists is to understand the mechanisms that discriminate between molecular interactions and determine function. Here, we show how partner recognition of the AXH domain of the transcriptional co-regulator ataxin-1 is fine-tuned by a subtle balance between self- and hetero-associations. Ataxin-1 is the protein responsible for the hereditary spinocerebellar atax...

To determine the functional role of the two isoforms of Fc gamma RIII (CD16) (IIIA, IIIB), the signal transduction capabilities of wild-type and mutant forms of these receptors were analyzed in transfected lymphoid, myeloid, and fibroblastic cell lines. Functional reconstitution of receptor signalling was observed in hematopoietic T and mast cells, and was absent in nonhematopoietic (CHO) cells...

Two diazaporphyrin (DAP)-porphyrin hetero dimers, in β-meso and β-β configurations, were prepared to study their photoinduced intramolecular electron transfer properties. The two meso nitrogen atoms in the porphyrin ring of DAP change its redox potential, making DAP more easily reduced, compared to its porphyrin counterpart. A charge-transfer from porphyrin to DAP in both hetero dimers was veri...

Members of the Hsp60 chaperonin family, such as Escherichia coli GroEL/S and the eukaryotic cytosolic chaperonin complex, TRiC (TCP ring complex), are double toroid complexes capable of assisting the folding of proteins in vitro in an ATP-dependent fashion. TRiC differs from the GroEL chaperonin in that it has a hetero rather than homo-oligomeric subunit composition and lacks a GroES-like regul...

A series of new benzimidazolium halides were synthesized in good yields as unsymmetrical N-heterocyclic carbene (NHC) precursors containing the N-CH₂-arene group. The benzimidazolium halides were readily converted into ruthenium(II)-NHC complexes with the general formula [RuCl₂(η⁶,η¹-arene-CH₂-NHC)]. The structures of all new compounds were characterized by ¹H NMR (Nuclear Magnetic Resonance), ...

An efficient Pd-catalyzed one-pot desulfinative cross-coupling to access medicinally relevant di(hetero)arylmethanes is reported. The method reductant-free, and involves a sulfinate transfer reagent Pd-catalyst mediating the union of two electrophilic coupling partners; (hetero)aryl halide benzyl halide. We establish for first time that sulfinates, generated in situ, undergo with halides genera...

Sequential embedding of metal complexes 4?-(pyridin-4-yl)-2,2?:6?,2??-terpyridine to a surface-enhanced supports pre-functionalized with templating layer results in hetero-bimetallic (Os–Fe, Co–Fe) and hetero-trimetallic (Co–Os–Fe) monolayer materials.