Background and Aim Lubiprostone is a novel laxative that sometimes causes nausea, but preventive strategies remain unconfirmed. Methods We retrospectively chose 126 patients prescribed lubiprostone from 2013 to 2016. Medical records were reviewed to clarify whether nausea developed after administration of the drug. Background characteristics, including concomitant medicines, were also reviewe...

BACKGROUND Age is the leading risk factor for acute and chronic neurodegenerative diseases. The Shen Nong Ben Cao Jing, the oldest known compendium of Chinese materia media, lists herbal medicines that were believed to exert neither fast acting pharmacological effects nor discernible toxicity, but to promote general health and longevity. In modern terms, these herbal medicines could be consider...

A retrospective analysis of all adverse experience reports received by the Australian Pesticides and Veterinary Medicines Authority's Adverse Experience Reporting Program for veterinary medicines since 1995, showed that permethrin toxicity in cats usually occurred after the owner applied a canine permethrin-containing product, typically a spot-on. Cats are also at risk from grooming or being in...

In the presented case, we got an herbal medicine in the form of a set of different color pills from local herbal medicinal practitioner. According to the advertisements on monograph, the product contains only herbal ingredients without any adequate declaration of the ingredients and was declared as anti-diabetic formulation. For identification of the ingredients, the pills were analyzed by UV, ...

Why Pharmacokinetics? Herbalists have long studied the effect of herbal medicines on the body, but have hitherto paid less attention to the effects of the body on herbal medicines. This dichotomy expresses the distinction in classical pharmacology between pharmacodynamics and pharmacokinetics. For a given dose of any herbal medicine, its physiological effect (or that of its constituents) will b...

Ten years have passed since Directive 2004/24/EC regulating herbal medicinal products across the EU were published. The directive created the Committee on Herbal Medicinal Products within the European Medicines Agency whose remit includes the creation and publishing of official EU monographs on herbal medicinal products. These monographs include the official uses of the products and their evide...

Anxiety and insomnia are two of the most prevalent mental health conditions a significant contributor to disability worldwide. We all experience feelings anxiety, fear, worry at many point in our lives. These can have negative impact on every individual’s physical if they persist for an extended period time. Clinical anxiety disorders result from this. be treated with variety methods also herba...

Pregnane and Xenobiotic Receptor (PXR), a vital xenosensor, acts as master regulator of phase-I (cytochrome P450) and phase-II enzymes (glutathione S-transferases, sulfotransferases, and uridine 5’-diphosphate glucuronosyltransferases) as well as several drug transporters (multi-drug resistance protein, and multidrug resistance-associated protein). PXR can bind to a variety of chemically distin...

In recent years we have witnessed the widespread use of herbal and traditional medicines. In many cases, people use traditional treatments arbitrarily and without consultation with a qualified person (1). As a teacher, I have frequently seen a number of my colleagues and others use herbal medicines and traditional methods for their medical problems. Looking at the papers published in this journ...