The targeted approach of protein kinases (PKs), as PKs are the main regulators cell survival and proliferation, has been a promising strategy for cancer treatments. Here we analyse potential quinoline-carboxamide derivatives four lines: MCF-7, CACO, HepG-2 HCT-116 anticancer agents. 3e, 4b, 11b 13d showed good anti-proliferative activities in comparison to reference standard Doxorubicin, agains...

BACKGROUND Many heterocyclic compounds containing thiazole or 1,3,4-thiadiazole ring in their skeletons have been reported to possess various pharmacological activities especially anticancer activities. RESULTS 4-Methyl-2-phenylthiazole-5-carbohydrazide (2) was used as a synthon to prepare 2-(4-methyl-2-phenylthiazole-5-carbonyl)-N-phenylhydrazinecarbothioamide (3) and 2-(2-(4-methyl-2-phenyl...

Thesis Abstract Triazines represent a promising scaffold for cancer treatment due to their similarity the biologically active purine and pyrimidine systems. Besides, triazines annulated compounds exist in skeleton of numerous natural synthetic chemotherapeutic agents such as Azanucleosides (6-azacytosine 6-azauracil). Also, triazine derivatives proved display antiviral, anti-inflammatory, antim...

In recent decades, the worldwide production of microalgae has been carried out on an industrial scale. years, market for natural products grown because changes in consumer preferences more products. The objective this study was to demonstrate hepatoprotective capacity fucoxanthin extract obtained from culture Phaeodactylum tricornutum (Culture Collection Alga and Protists Scotland). microalga a...

Herein in this article, three new Ca(II), Zn(II) and Au(III) complexes of sulfamethoxazole (SZ) (sulfa-drug) have been synthesized for the first time. The sulfa-drugs have a great attentions because of their therapeutic applications against bacterial infections. The SZ complexes were discussed with the help of elemental analyses, molar conductance and spectroscopic instruments e.g. IR, 1H-NMR, ...

Six novel copper(ii) complexes of [CuCl]ClO4 (), [Cu(acac)]PF6 (), [CuCl]2(PF6)2 (), [CuCl]2(PF6)2 (), [Cu(acac)]PF6 () and [Cu(acac)]PF6 (), ( = 1-naphthyl-N,N-[bis(2-pyridyl)methyl]amine, = R/S-1-naphthyl-N,N-[bis(2-pyridyl)methyl]ethanamine, acac = diacetone) were synthesized to serve as artificial nucleases. All complexes were structurally characterized using X-ray crystallography. The crys...

Abstract Colorectal cancer is one of the leading causes deaths worldwide. Currently, chemotherapy primary way for colorectal cancer, but with severe side effects. Therefore, it urgent to find safer and more effective adjuvant treatment methods. At present, natural active substances are promising alternatives, as numerous studies have demonstrated possible synergistic anticancer effects in plant...

Hollow fibre cell fishing with HPLC (HFCF-HPLC) based on the human ovarian cancer cell line SKOV-3, human renal tubular cell line ACHN or hepatoma cell line HepG-2 was employed to screen active groups of coumarin and volatile oil in Radix angelicae sinensis, Radix angelicae dahuricae and Fructus citri sarcodactylis. Simultaneously, hollow fibre liquid phase microextraction with HPLC (HFLPME-HPL...

The current study sought to assess the antitumor, anticancer, and antioxidant efficacy of Ulva lactuca-mediated selenium nanoparticles by using an in vitro model human hepatocellular carcinoma (HepG-2 cells) HAV HM175 strain hepatitis A virus, with evaluation activity conducted DPPH assay. showed promising cytotoxicity at highest concentrations 250 500 µg/mL, viability rates 19.43 8.75% for can...