نتایج جستجو برای: hepatoma

تعداد نتایج: 8343  

2007
H. P. MORRIS

The administration of t ryptophan or cortisone to rats bearing the Morris 5123 Hepatoma resulted in significant increases in t ryptophan pyrrolase activity in the host liver but in no change in the low tryptophan pyrrolase activity of the neoplasm. The repressed level of this enzyme in the neoplasm was not a result of the lack or excess of cofactors or enzymes necessary for the assay procedure ...

Journal: :Toxicologic pathology 1984
T Galeotti S Borrello G Minotti G Palombini L Masotti G Sartor P Cavatorta A Arcioni C Zannoni

Studies were carried out on microsomes isolated from the highly differentiated (slow-growing) Morris hepatoma 9618A, on microsomes and plasma membranes from the poorly differentiated (fast-growing) Morris hepatoma 3924A, and rat liver used as control. The lipid composition (phospholipid and cholesterol content, degree of fatty acid unsaturation) and peroxidation of such membranes has been corre...

2017
Yuki Haga Tatsuo Kanda Masato Nakamura Shingo Nakamoto Reina Sasaki Koji Takahashi Shuang Wu Osamu Yokosuka

BACKGROUND Despite recent advances in treatment strategies, it is still difficult to cure patients with hepatocellular carcinoma (HCC). Sorafenib is the only approved multiple kinase inhibitor for systemic chemotherapy in patients with advanced HCC. The majority of advanced HCC patients are resistant to sorafenib. The mechanisms of sorafenib resistance are still unknown. METHODS The expressio...

2016
Fanyun Kong Wei Hu Kai Zhou Xiao Wei Yanbo Kou Hongjuan You Kuiyang Zheng Renxian Tang

BACKGROUND Interleukin-7 receptor (IL-7R) is involved in the abnormal function of solid tumors, but the role and regulatory mechanisms of IL-7R in HBV-related hepatocellular carcinoma (HCC) are still unclear. METHODS Gene and protein expression levels of IL-7R were examined in hepatoma cells transfected with hepatitis B virus (HBV) plasmids and in hepatoma cells transfected with the multifunc...

Journal: :The Journal of the Association of Physicians of India 2006
N Jayaprasad T Anees T Bijin S Madhusoodanan

Hypoglycemia is a well documented paraneoplastic syndrome of hepatoma. Hypoglycemia as sole presentation is very rare. We report a case of poorly differentiated hepatoma with multiple lung metastases presenting with recurrent hypoglycemic seizures as the only manifestation four months before the diagnosis of the tumour.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1977
E Bustamante P L Pedersen

A tumorigenic anchorage-dependent cell line (H-91) was established in culture from an azo-dye-induced rat ascites hepatoma. When grown in a glucose-containing medium the cells exhibit high rates of lactic acid production characteristic of rapidly growing tumor cells. However, when glucose is replaced with galactose the cells grow equally well but exhibit only moderately elevated rates of lactic...

2014
Tao Hu Qingyun Du Fu Ren Shi Liang Denan Lin Jiajia Li Yan Chen

BACKGROUND Hepatoma associated with hepatitis B infection is a major public health problem in Shenzhen (China) and worldwide. China has the largest number of people infected with the hepatitis B virus (HBV), and many studies have demonstrated that HBV infection is associated with hepatoma development. Shenzhen officials have been attempting to monitor and control these diseases for many years. ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Satoshi Matsumura Issei Imoto Ken-ichi Kozaki Takeshi Matsui Tomoki Muramatsu Mayuko Furuta Shinji Tanaka Michiie Sakamoto Shigeki Arii Johji Inazawa

PURPOSE The aim of this study was the identification of novel tumor suppressor genes (TSG) silenced by DNA hypermethylation in hepatocellular carcinoma (HCC). EXPERIMENTAL DESIGN We conducted integrative array-based approach for genome-wide screening of methylation targets using a methylated DNA immunoprecipitation-CpG island microarray and expression array in three universal hepatoma cell li...

2012
Jingwei Ma Chunmei Huang Xinxin Yao Chuan Shi Lifang Sun Lu Yuan Ping Lei Huifen Zhu Hongbo Liu Xiongwen Wu Qin Ning Chun Zhou Guanxin Shen

Hepatitis B virus (HBV) infection is a worldwide liver disease and nearly 25% of chronic HBV infections terminate in hepatocellular carcinoma (HCC). Currently, there is no effective therapy to inhibit HBV replication and to eliminate hepatoma cells, making it highly desired to develop novel therapies for these two stages of the HBV-caused detrimental disease. Recently, short hairpin RNA (shRNA)...

2011
Haiou Liu Jiejie Xu Lei Zhou Xiaojing Yun Lin Chen Shanshan Wang Linlin Sun Yumei Wen Jianxin Gu

There are three hepatitis B virus (HBV) envelope glycoproteins collectively known as hepatitis B virus surface antigen (HBsAg), including the large (LHBs), middle (MHBs), and small (SHBs) surface proteins. Among them, LHBs has been retained in a large proportion of liver tissues in HBV-associated hepatocellular carcinoma (HCC) patients and shown oncogenic function in transgenic mice. However, t...

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