Antiviral drugs have an established role in the management of selected patients with chronic viral hepatitis. Of the hepatitis viruses (A to E), hepatitis B virus (HBV), hepatitis C virus (HCV) and hepatitis D virus (HDV) (also called delta virus) cause chronic hepatitis with the potential for development of cirrhosis and its complications, including primary hepatocellular carcinoma (HCC). HDV ...

Results A total of 49 cases fit the inclusion criteria. Most were male (90%), with a median (IQR) age of 42.6 (39-46.7) years-old. Eighteen (36.7%) were or had been chronic infected by HCV. Among HBsAg+ patients, 19 (41.3%) were HBeAg+ and 13 (26.5%) were superinfected by the hepatitis delta virus (HDV). No differences were found in the distribution of CC genotypes when comparing patients with ...

results overall, 3 (15%) subjects achieved svr, 10 cases (50%) relapsed after treatment cessation and 7 (35%) patients did not clear hdv during the treatment. conclusions hdv coinfection with hbv had very low response rate to high doses and long durations of ifn α-2b therapy. objectives we aimed to determine the efficacy of ifn α-2b therapy in patients with hbv/hdv coinfection. patients and met...

The Miyako Islands, located in the southernmost part of Japan, have been reported to be endemic for hepatitis delta virus (HDV). The majority of HDV patients in this area exhibit a relatively mild course of infection that evolves into a quiescent cirrhotic condition. The entire nucleotide sequence of the Miyako isolate (L215) of HDV obtained from a cirrhotic patient infected with HDV was determ...