Background: One of the major paths for drug development is the study of bioactivities of natural products. Therefore, the aim of this study was to compare the cytotoxic effects of aqueous extract of whole Cuscuta chinensis Lam., which is a traditional medicinal herb commonly used in Iran and other oriental countries, on the human caucasian acute lymphoblastic leukemia (CCRF-CEM) and another hum...

Background: Colon cancer is one of the most diagnosed cancers in modern world. Chemotherapy relevant treatments for colon cancer, but this method treatment has severe and sometimes irreversible side effects. Therefore, alternative with fewer effects are highly considered. Natural herbal medicine been proven to be a great source these methods. Objectives: This study aimed investigate anti-prolif...

Here we report a method for efficient transfection of in vitro-transcribed mRNA into two different types of human adherent cells, the neuroblastoma cell line SK-N-AS, and the transformed kidney cell line HEK293. By using newly trypsinized adherent cells in suspension and Lipofectaminetrade mark 2000, we detected a transfection efficiency of 80-90% in both cell lines and a cell viability of 90% ...

Background:Gossypol is a yellow toxic pigment from the cottonseed that can cause acute or chronic toxicity in humans and animals by affecting the testicular tissues. Nowadays cottonseed is used as food supplement for ruminants specially the sheep. In this study, two different stem cell lines of testicular tissue including GC1-spg (mouse testis) and SFTF-PI43 (sheep testis) cells were used to ev...

abstract cytotoxic effect of extract leaves of t. kotschyanus boiss. & hohen on human lang cell. t. kotschyanus boiss. & hohen was used in traditional medicine such as anti-inflammation, antispasmodic and gastrointestinal aim of this study was to survey the cytotoxic effects the of ethanol of leave of thymus kotschyanus on a-549 cell line. t. kotschyanus was collected on spring 2014 from selsel...

Objective(s): Acquisition of TNF-α resistance plays role in the onset and growth of malignant tumors. Previous studies have demonstrated that MCF-7 cell line and its doxorubicin resistant variant MCF-7/Adr are resistant against the cytotoxic effects of TNF-α. In this study, we investigated the role of Akt activation in resistance of MCF-7 and MCF-7/Adr against TNF-α cytotoxicity. Materials and ...

introduction: this in vitro study compared the cytotoxic effects of three commercially available mta formulations naming proroot mta (pmta), angelus mta (amta), and root mta (rmta), with calcium-enriched mixture (cem) cement and a new nanohybrid mta (nmta) on human dental pulp stem cells (dpsc). methods and materials: four disc-shaped specimens of each material were prepared. after completion o...