Pyruvate produces inotropic responses in the adult reperfused heart. Pyruvate oxidation and anaplerotic entry into the tricarboxylic acid (TCA) cycle via carboxylation are linked to the stimulation of contractile function. The goals of this study were to determine if these metabolic pathways operate and are maintained in the developing myocardium after reperfusion. Immature male swine (age: 10-...

The intermediate filament protein nestin was identified in diverse populations of cells implicated in cardiovascular remodeling. Cardiac resident neural progenitor/stem cells constitutively express nestin and following an ischemic insult migrate to the infarct region and participate in angiogenesis and neurogenesis. A modest number of normal adult ventricular fibroblasts express nestin and the ...

TREATMENT of cardiac failure usually includes several therapeutic maneuvers that are used concurrently in order to restore the state of compensation: (1) elimination of the overload due to exercise or emotional stress, which can be accomplished by rest, (2) enhancemenat of performance of the heart by the administration of cardiotonic drugs, of which digitalis is the principal one, (3) decrease ...

Therapies for heart disease are based largely on our understanding of the adult myocardium. The dramatic differences in action potential (AP) shape between neonatal and adult cardiac myocytes, however, indicate that a different set of molecular interactions in neonatal myocytes necessitates different treatment for newborns. Computational modeling is useful for synthesizing data to determine how...

A cohort of 1,960 white men aged 40 to 56 years without initial apparent heart disease and with 11 years of annual rest electrocardiograms and 20 year mortality data was followed in the Chicago Western Electric Company Study. Incomplete right bundle branch block was found in 134 men (6.8%) at entry. During follow-up, 222 men developed such block, an incidence rate of 13.6%. Left axis deviation ...

OBJECTIVE To reduce the probability of failure in the oral chemotherapy order, review and administration process and to reduce oral chemotherapy-related prescribing errors intercepted by clinical pharmacists prior to reaching the patient. DESIGN A before-and-after cohort study. SETTING A 719-bed multidisciplinary tertiary care institution with a pediatric division and an outpatient cancer c...

The present study was undertaken to examine cardiac responses to some of the temperature challenges that eels encounter in their natural environment. The contractile properties of ventricular muscle was studied on electrically paced tissue strips after long term acclimation at 0 °C, 10 °C, or 20 °C, and following acute ± 10 °C temperature changes. The time-course of contraction, and thus maxima...

The roles of cGMP, prostaglandins, the entry of extracellular Ca2+ through slow channels, endothelium and V1 receptors in the negative inotropic, chronotropic and coronary vasoconstrictor responses to arginine vasopressin (AVP) have been investigated in isolated perfused rat hearts. The bolus injection of 5 x 10(-5) M AVP produced a significant decrease in contractile force, heart rate and coro...

AIM To establish whether ECG findings are associated with subsequent risk of sudden death from coronary heart disease (CHD). METHODS AND RESULTS Potential risk factors for CHD were measured at entry to the first Northwick Park Heart Study of 2167 men. ECG findings were coded as high or low risk for CHD according to definitions in the Minnesota code. Sudden or non-sudden deaths were defined as...

OBJECTIVES To evaluate a Framingham risk function for coronary heart disease in an elderly Australian cohort and to derive a risk function for cardiovascular disease (CVD) in elderly Australians. DESIGN AND SETTING Analysis of data from a prospective cohort study (the Dubbo Study) in a semi-urban town (population, 34 000). PARTICIPANTS 2805 men and women 60 years and older living in the com...