BACKGROUND The most important complication of atrial fibrillation (AF) is thromboembolic stroke. Although AF-related remodeling is considered important in atrial thrombogenesis, its role never has been directly tested. This study assessed effects of AF-related remodeling on the atrial thrombogenic milieu by using radiofrequency ablation (RFA) to create a quantifiable prothrombotic nidus. METH...

This technique provides a method for demonstrating the principal branches of the coronary arteries, and the larger cardiac veins. At the same time a cast of the cavities of the heart is produced. Although a relatively low injection pressure is used, the thin-walled cavities of the atria and the right ventricle are considerably distended, so that the cast of these cavities is larger than the cav...

Based on the sequentiality principle, this review proposes a practical method that allows the systematization of the anatomic diagnosis of congenital heart disease. We emphasize the need to use sequential connection between the different cardiac segments: atria, ventricles and great arteries. Five ordered steps are defined, which include determination of atrial situs and of the connection featu...

戸田 昇 ・藤原 元始 ・島本暉 朗 Hukovic (1) was the first to suggest the existence of the cholinergic fibers in the sympathetic nerve of the rabbit's atria. He showed that stimulation of the sympathetic nerve in the isolated reserpinized heart produced the negative chrono and inotropic effects which were potentiated by eserine and abolished by atropine. A series of ex periments in this laboratory (2-5) have...

The developmental appearance and spatial distribution pattern of gap junctions were studied in prenatal and adult rat hearts. Gap junctions were visualized immunohistochemically with an antibody raised against a unique cytoplasmic epitope of connexin43, and the spatial distribution pattern was determined by three-dimensional reconstruction. The results demonstrate that from embryonic day 13 onw...

The effects of sex hormones on the heart are dependent on the presence and distribution of sex steroid hormone receptors (SSHR) in cardiac tissue. This study used subcellular fractionation, Western blot analysis and densitometry to characterize the subcellular distribution and abundance of estrogen receptor (ER) alpha, ERbeta and androgen receptor (AR) in atrial and ventricular tissue from male...

Three patients with Emery Dreifuss muscular dystrophy are reported. Emery Dreifuss muscular dystrophy is an X linked muscular dystrophy, in which locomotor involvement is characteristically mild and slowly progressive. The effect on the heart becomes apparent in the teenage years and is characterised by cardiac conduction defects and infiltration of the myocardium by fibrous and adipose tissue....

Garlic juice (dose equivalent to 3.3 g to 33 g garlic) mainly caused bradycardia in frog Rana tigerina. The disturbance in ventricular rhythm was observed prior to than that of atria. Rhythm was specially disturbed at higher doses causing bizarre pattern. Force of contraction of the heart also decreased with higher dose of the garlic extract. The results suggest that garlic extract has some ben...

Atrial fibrillation (AF), the most commonly encountered arrhythmia in clinical practice, is associated with significant morbidity and mortality. Of great significance are heart failure and stroke.1 With increased incidence and prevalence of AF, it represents a growing clinical and economic burden. AF is also a progressive disease secondary to continuous structural remodeling of the atria becaus...

Mathematical models of the human heart are evolving to become a cornerstone precision medicine and support clinical decision making by providing powerful tool understand mechanisms underlying pathophysiological conditions. In this study, we present detailed mathematical description fully coupled multi-scale model heart, including electrophysiology, mechanics, closed-loop circulation. State-of-t...