OBJECTIVE Subarachnoid hemorrhage (SAH) is a recently identified risk factor for hypopituitarism, particularly growth hormone (GH) and corticotrophins deficiencies. The aim of our study was to identify possible predictor(s) for neuroendocrine dysfunction in SAH survivors. DESIGN Pituitary function was evaluated in 93 patients (30 males, 63 females), aged 48.0+/-1.1 years (mean+/-SE), and with...

Hypodermoclysis (HDC) had fallen into disrepute after adverse clinical incidents that were obviously the result of improper use of an ingenious technique. HDC has clear advantages over alternative parenteral routes. It has stood the rigour of scientific scrutiny but failed to regain its past glory. This is possibly because of our ignorance and inability to detach ourselves from an age-old preju...

BACKGROUND Chronic cardiac dysfunction may develop after administration of aggressive chemotherapy, sometimes leading to development of congestive heart failure (CHF). Recently, N-terminal pro-B-type natriuretic peptide (NT-proBNP) was implicated as a marker of CHF. In this study we evaluated the predictive role of NT-proBNP in patients treated with high-dose chemotherapy (HDC). METHODS NT-pr...

Hyperdimensional computing (HDC) is an emerging computational framework inspired by the brain that operates on vectors with thousands of dimensions to emulate cognition. Unlike conventional frameworks operate numbers, HDC, like brain, uses high-dimensional random and capable one-shot learning. HDC based a well-defined set arithmetic operations highly error resilient. The core manipulate HD in b...

Fuzzy clustering decomposes data into clusters using partial memberships by exploring the cluster structure information, which demonstrates comparable performance for knowledge exploitation under circumstance of information incompleteness. In general, this scheme considers objects to centroids and applies with spherical distribution. addition, noises outliers may significantly influence process...

measles virus (mv) is a highly contagious agent which causes a major health problem in developing countries. we studied the effect of buthionine sulfoximine (bso) on the replication of an aik-hdc strain of mv and its induced apoptosis in vero cell lines. methods: in this study, toxicity of bso on vero cells was investigated first, resulted in determination of sub-lethal or non-toxic concentrati...

Breast cancer is the leading cause of death for American women. Metastatic breast cancer, the focus of this paper, is defined as cancer that originated in the breast and has moved to lymph nodes and other bodily tissues. The treatment researched here is high-dose chemotherapy (HDC) followed by an autologous stem cell transplantation (ASCT). The safety and efficacy of HDC/ASCT are still under ex...

the governments of the People's Republic of China and Portugal through a contribution to the UNU Endownment Fund. As well as providing two-thirds of the endownment fund, the Macau authorities also supply UNU/IIST with its ooce premises and furniture and subsidise fellow accommodation. The mission of UNU/IIST is to assist developing countries in the application and development of software techno...

BACKGROUND We conducted a phase I-II trial to assess the feasibility and activity of a combination chemotherapy regimen with etoposide, ifosfamide, cisplatin or carboplatin, and epirubicin in limited-disease (LD, stages I-IIIB) and extensive-stage (ED, stage IV) small-cell lung cancer (SCLC). PATIENTS AND METHODS Standard-dose chemotherapy (SDC) consisting of etoposide (500 mg/m2), ifosfamide...

BACKGROUND AND OBJECTIVE Concerns about the risk of transfusion therapy are driving towards new strategies which are designed to minimize exposure to allogeneic blood products. We aimed to find out whether it is possible to support the phase of thrombocytopenia following high-dose chemotherapy (HDC) and circulating progenitor cells (CPC) transplantation by autologous platelet concentrates (PC)....