نتایج جستجو برای: hcv genome

تعداد نتایج: 249841  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Sharookh B Kapadia Amy Brideau-Andersen Francis V Chisari

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease, which can lead to the development of liver cirrhosis and hepatocellular carcinoma. Current therapy of patients with chronic HCV infection includes treatment with IFNalpha in combination with ribavirin. Because most treated patients do not resolve the infection, alternative treatment is essential. RNA interference (RNAi...

2015
Joseph C. Forbi Jennifer E. Layden Richard O. Phillips Nallely Mora Guo-liang Xia David S. Campo Michael A. Purdy Zoya E. Dimitrova Dorcas O. Owusu Lili T. Punkova Pavel Skums Shirley Owusu-Ofori Fred Stephen Sarfo Gilberto Vaughan Hajung Roh Ohene K. Opare-Sem Richard S. Cooper Yury E. Khudyakov Jason Blackard

Globally, hepatitis C Virus (HCV) infection is responsible for a large proportion of persons with liver disease, including cancer. The infection is highly prevalent in sub-Saharan Africa. West Africa was identified as a geographic origin of two HCV genotypes. However, little is known about the genetic composition of HCV populations in many countries of the region. Using conventional and next-ge...

Journal: :Journal of clinical microbiology 1995
J Odeberg Z Yun A Sönnerborg M Uhlén J Lundeberg

In the present study, we used a semiautomated solid-phase direct sequencing method to analyze sequence diversity and variation of the hypervariable E2/NS1 region in the hepatitis C virus (HCV) genome in isolates from patients seropositive for HCV. A total of 24 isolates of various origins were sequenced. Six of the patients, not subject to any antiviral therapy, were monitored longitudinally, a...

2006
Shelton S. Bradrick Robert W. Walters Matthias Gromeier

Enhancement of eukaryotic messenger RNA (mRNA) translation initiation by the 30 poly(A) tail is mediated through interaction of poly(A)-binding protein with eukaryotic initiation factor (eIF) 4G, bridging the 50 terminal cap structure. In contrast to cellular mRNA, translation of the uncapped, non-polyadenylated hepatitis C virus (HCV) genome occurs independently of eIF4G and a role for 30-untr...

2013
Hazel Stewart Cheryl Walter Dale Jones Sinead Lyons Peter Simmonds Mark Harris

The 5' untranslated region (5'UTR) of the recently described non-primate hepacivirus (NPHV) contains a region with sequence homology to the internal ribosomal entry site (IRES) of hepatitis C virus (HCV) and GB virus B (GBV-B). Here, we demonstrated internal translation initiation by the NPHV 5'UTR in a bicistronic vector. An RNA stem-loop upstream of the NPHV IRES was structurally distinct fro...

Journal: :Nucleic acids research 1989
Y Kubo K Takeuchi S Boonmar T Katayama Q L Choo G Kuo A J Weiner D W Bradley M Houghton I Saito

Recently, a cDNA from the hepatitis C virus (HCV) RNA genome has been isolated in the USA from a chronically infected chimpanzee. In order to isolate HCV cDNA derived from human material, RNA was extracted from plasma of a Japanese blood donor implicated in post-transfusion non-A, non-B hepatitis and HCV cDNA was synthesized and amplified by the PCR method using HCV-specific oligonucleotide pri...

Journal: :Journal of virology 2003
Preeti Pancholi Marion Perkus Nancy Tricoche Qingyan Liu Alfred M Prince

We studied immune responses to hepatitis C virus (HCV) genes delivered as DNA encoding the entire HCV protein coding genome in two polycistronic plasmids encoding HCV capsid-E1-E2-NS2-NS3 and HCV NS3-NS4-NS5 in HLA-A2.1-transgenic mice. Immune responses to HCV DNA prime and recombinant canarypox virus boost were also studied with the above constructs. At 8 weeks after a canarypox virus boost, t...

Journal: :The Journal of general virology 2008
Takashi Kimura Michio Imamura Nobuhiko Hiraga Tsuyoshi Hatakeyama Daiki Miki Chiemi Noguchi Nami Mori Masataka Tsuge Shoichi Takahashi Yoshifumi Fujimoto Eiji Iwao Hidenori Ochi Hiromi Abe Toshiro Maekawa Keiko Arataki Chise Tateno Katsutoshi Yoshizato Takaji Wakita Toru Okamoto Yoshiharu Matsuura Kazuaki Chayama

The establishment of clonal infection of hepatitis C virus (HCV) in a small-animal model is important for the analysis of HCV virology. A previous study developed models of molecularly cloned genotype 1a and 2a HCV infection using human hepatocyte-transplanted chimeric mice. This study developed a new model of molecularly cloned genotype 1b HCV infection. A full-length genotype 1b HCV genome, H...

Journal: :The Journal of general virology 2015
Patricia Domingues Connor G G Bamford Chris Boutell John McLauchlan

Chronic infection of the liver by hepatitis C virus (HCV) induces a range of host factors including IFN-stimulated genes such as ISG15. ISG15 functions as an antiviral factor that limits virus replication. Previous studies have suggested that ISG15 could influence HCV replication in both a positive and a negative manner. In this report, we determined the effect of ISG15 on HCV RNA replication i...

Journal: :Nucleic Acids Research 2006
Shelton S. Bradrick Robert W. Walters Matthias Gromeier

Enhancement of eukaryotic messenger RNA (mRNA) translation initiation by the 3' poly(A) tail is mediated through interaction of poly(A)-binding protein with eukaryotic initiation factor (eIF) 4G, bridging the 5' terminal cap structure. In contrast to cellular mRNA, translation of the uncapped, non-polyadenylated hepatitis C virus (HCV) genome occurs independently of eIF4G and a role for 3'-untr...

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