— Iron 57-enriched, deoxygenated human (adult) hemoglobin (HbA), its isolated asHand /?sn-chains, and the partially iron 57-enriched, fully functional hemoglobin a2(Fe) j82(Fe) were investigated by Mossbauer spectroscopy in the temperature range 4.2 K-200 K. According to our experimental accuracy ( ± 0.006 mm s) the temperature dependent quadrupole splittings &EQ(T) of deoxygenated HbA, <XSHand...

The functional divergence of duplicated genes is thought to play an important role in the evolution of new developmental and physiological pathways, but the role of positive selection in driving this process remains controversial. The objective of this study was to test whether amino acid differences among triplicated alpha-globin paralogs of the Norway rat (Rattus norvegicus) and the deer mous...

AIMS To assess the numeracy and literacy skills of individuals with Type 1 diabetes and determine if there is a relationship with achieved glycaemic control independent of their duration of diabetes, diabetes education, demographic and socio-economic factors. METHODS One hundred and twelve patients completed the study (mean current age 43.8 ± 12.5 years, 47% male, mean duration of diabetes 22...

Haemoglobins are iron-containing proteins that transport oxygen in the blood of most vertebrates. The mitochondrion is the cellular organelle which consumes oxygen in order to synthesise ATP. Mitochondrial dysfunction is implicated in neurodegeneration and ageing. We find that α and β haemoglobin (Hba and Hbb) proteins are altered in their distribution in mitochondrial fractions from degenerati...

BACKGROUND Improved glycemic control reduces complications in patients with diabetes mellitus (DM). However, it is discussed controversially whether patients with diabetes mellitus and end-stage renal disease benefit from strict glycemic control. METHODS We followed 78 patients with DM initiating dialysis treatment of the region of Vorarlberg in a prospective cohort study applying a time-depe...

Deep Eutectic Monomers were prepared by dissolution of selected tetrabutylammonium salts serving as hydrogen bond acceptors (HBA) in methacrylic acid (MAA) acting both donor (HBD) and vinyl monomer. In this study, we systematically investigate the influence chloride, nitrate, hydrogensulphate fluoroborate anions on properties DEMs course radical photopolymerization. By Combining FTIR, 1H 13C NM...

OBJECTIVE To determine the effects of nateglinide added to rosiglitazone monotherapy on glycemic control and on postprandial glucose and insulin levels in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS This 24-week, multicenter, double-blind, randomized study compared the efficacy of nateglinide (120 mg a.c.) and placebo added to rosiglitazone monotherapy (8 mg q.d.) in 402 patien...

Whether hemoglobin A(1c) (HbA(1c)) values are suitable for diagnosing diabetes has been debated. We sought to assess the prevalence of elevated HbA(1c) levels in a prediabetes patient population. Oral glucose tolerance tests and HbA(1c) levels were analyzed for patients entering a diabetes prevention program between January 1, 2007, and September 13, 2009. We calculated the percentage of patien...

Glycated hemoglobin (HbA(1c)) is a parameter broadly employed in the assessment of glycemic control in diabetes. The 2010 "Standards of medical care in diabetes", published by the American Diabetes Association (ADA), recommended performing the HbA(1c) test at least every 6 months in patients in whom disease is clinically stable, while subjects after modifications of therapy or in whom glycemic ...

OBJECTIVE To compare the associations of nontraditional (fructosamine, glycated albumin, 1,5-anhydroglucitol [1,5-AG]) and standard (fasting glucose, HbA(1c)) glycemic markers with common microvascular conditions associated with diabetes mellitus. RESEARCH DESIGN AND METHODS We conducted a cross-sectional study of 1,600 participants (227 with a history of diabetes and 1,323 without) from the ...