By means of a multimass isotropic and spherical model including self-consistently a central intermediate-mass black hole (IMBH), the influence of this object on the morphological and physical properties of globular clusters is investigated in this paper. Confirming recent numerical studies, it is found that a cluster (with mass M) hosting an IMBH (with mass M•) shows, outside the black hole gra...

By means of a multimass isotropic and spherical model including self-consistently a central intermediate-mass black hole (IMBH), the influence of this object on the morphological and physical properties of globular clusters is investigated in this paper. Confirming recent numerical studies, it is found that a cluster (with mass M) hosting an IMBH (with mass M•) shows, outside the black hole gra...

Solution and cell studies were performed to ascertain why individuals with hemoglobin (Hb) SC have disease whereas those with Hb AS do not. The polymerization of deoxygenated mixtures containing sickle cell Hb (Hb S; alpha 2 beta 2(6)Glu leads to Val) and Hb C (alpha 2 beta 2(6)Glu leads to Lys) was investigated by measurements of delay times and solubilities. In mixtures containing more than 4...

The critical O(2) tension of whole-animal O(2) consumption rate (M(O2)), or P(crit), is the water P(O2) (Pw(O(2))) at which an animal transitions from an oxyregulator to an oxyconformer. Although P(crit) is a popular measure of hypoxia tolerance in fishes because it reflects the capacity for O(2) uptake from the environment at low Pw(O(2)), little is known about the interrelationships between P...

BACKGROUND Anemia in pregnancy is common in Tanzania, but many areas have not been investigated. This study describes prevalence and determinants of anemia among rural pregnant women living at 1300-2200 meters above sea level in Northern Tanzania. METHODS Three thousand eight hundred and thirty-six pregnant women from two rural divisions of Mbulu and Hanang districts attending antenatal clini...

BACKGROUND This study aimed to analyze the on heart rate, blood lactate concentration, packed cell volume (PCV) and hemoglobin (Hb) response after conducting exercise in endurance horses. METHODS A total of 20 healthy 3-9-years-old Jeju crossbreed mares (5.95 ± 2.24 year) of age and 312.65 ± 13.59 kg of weight) currently participating the endurance competition were used. The field tests selec...

An impact of 0.5 to 3 M choline dihydrogen phosphate, [ch][dhp], the biotechnologically relevant ionic substance, on the thermal stability of a model globular protein, α-chymotrypsin (α-CT), has been studied exploiting the highly sensitive differential scanning calorimetry (DSC) technique. The notable overall stabilizing effect of 11 ± 2 K regarding the thermal transition (melting) temperature,...

Although guanosine 3',5'-cyclic monophosphate (cGMP) acts as a relaxant second messenger, the regulation of intracellular cGMP has not been comprehensively studied in human airway smooth muscle. We studied the production of cGMP by cultured human airway smooth muscle cells (HASMC) after stimulation with activators of soluble guanylyl cyclase [sodium nitroprusside (SNP) and S-nitroso- N-acetylpe...

Recent studies using chemiluminescence and spectrophotometry have shown that cultured and native endothelial cells release nitric oxide (NO). Pharmacological and biochemical evidence argue for and against the proposal that endothelium-derived relaxing factor (EDRF) is identical with free NO. In an attempt to identify EDRF as free NO, a bioassay technique was combined with an NO trap (hemoglobin...

Dissociation of both human deoxyhemoglobin (deoxy-Hb) and carboxyhemoglobin (HbCO) at alkaline pH exposes previously buried tyrosine residues to the environment and alters their PK. Subunit association and dissociation of deoxy-Hb and HbCO can be followed through spectral changes which arise from these changes in tyrosine ionization above pH 10.0. The difference spectrum of the dissociation rea...