Locally weighted polynomial regression LWPR is a popular instance based al gorithm for learning continuous non linear mappings For more than two or three in puts and for more than a few thousand dat apoints the computational expense of pre dictions is daunting We discuss drawbacks with previous approaches to dealing with this problem and present a new algorithm based on a multiresolution search...

In machine learning, linear discriminant analysis (LDA) is a popular dimension reduction method. In this paper, we first provide a new perspective of LDA from an information theory perspective. From this new perspective, we propose a new formulation of LDA, which uses the pairwise averaged class covariance instead of the globally averaged class covariance used in standard LDA. This pairwise (av...

Physarum displays two vegetative cell types, uninucleate myxamoebae and multinucleate plasmodia. Mutant myxamoebae of Physarum resistant to the antitubulin drug methylbenzimidazole-2-yl-carbamate (MBC) were isolated. All mutants tested were cross-resistant to other benzimidazoles but not to cycloheximide or emetine. Genetic analysis showed that mutation to MBC resistance can occur at any one of...

The limited use of decision aids has been a conundrum in our field for years, and Highhouse’s (2008) article is one of several attempts to explain and solve the problem. Lawshe and Bolda (1958) argued that managers could not understand themetric of validity coefficients, so they developed a more user-friendly metric, the expectancy chart. Others suggested that managers were not aware of the eco...

The development of the mammalian kidney, or metanephros, occurs in a region of posterior intermediate mesoderm by inductive interactions between the metanephric mesenchyme and the ureteric bud epithelium (Kuure et al., 2000; Lechner and Dressler, 1997; Schedl and Hastie, 2000). Induction of the mesenchyme by signals emanating from the bud initiates the aggregation of the mesenchyme and the conv...

Tree-based models provide an alternative to linear models for classification and regression data. They are used primarily for exploratory analysis of complex data or as a diagnostic tool following a linear model analysis. They are also used as the end product in certain applications, such as speech recognition, medical diagnoses, and other instances where repeated fast classifications are requi...

This document provides details on the random forest implementation and describes the 56 public data sets used in the empirical analysis. Random forest. We used the implementation of random forest in the R package randomForest (Liaw and Wiener, 2002). Typically, the only parameter tuned when using random forests is mtry, which specifies how many attributes should be randomly selected for conside...

Thionins are Cys-rich plant polypeptides of about 5 kD that are synthesized as larger precursors, which include a typical signal peptide and a posttranslationally processed, C-terminal peptide, and are thought to be involved in plant defense (García-Olmedo et al., 1989, 1991, 1992). We have previously reported on a nove1 neutral thionin type in wheat (Triticum aestivum L.), designated type V, w...

Locally weighted polynomial regression (LWPR) is a popular instance-based algorithm for learning continuous non-linear mappings. For more than two or three inputs and for more than a few thousand dat-apoints the computational expense of predictions is daunting. We discuss drawbacks with previous approaches to dealing with this problem, and present a new algorithm based on a multiresolution sear...

4 January 2014 M ILLER’S Pyramid of Assessment, the well-recognized and widely used model for the development and assessment of medical competence, defines four stages of capability: “knows,” “knows how,” “shows how,” and “does.”1 Each stage builds on the prior and each stage requires specific assessment tools. Nearly 4 decades of experience with the Objective Structured Clinical Examination (O...