background: breast cancer is one of the most common cancers in the world, particularly in iran. there are many genomic and molecular factors that cause the occurrence of breast cancer. many markers are associated with tumor invasiveness. matrix metalloproteinase includes a family of zinc-dependent endopeptidases that degrade various components of the extracellular matrix and basement membrane. ...

Background: Aggressive fibromatosis is a rare benign tumor with no potential for metastasis; however, its aggressive nature causes treatment failure and episodes of recurrence. There is no report from Iran about the treatment of this tumor, and all published articles are single-case reports, therefore in this study, we report our experience from two of...

Although microsatellite instability-high (MSI-H) colorectal cancers (CRCs) have been shown to exhibit a distinct phenotype, the clinical value of MSI-low (MSI-L) in CRC remains unclear. We designed this study to examine the clinicopathologic characteristics and oncologic implications associated with MSI-L CRCs. We retrospectively reviewed data of CRC patients from 3 tertiary referral hospitals ...

We would like to congratulate Skinner and colleagues on their recent article, in which they perform a thorough statistical comparison of multiple uveal melanoma classification systems that are based on anatomic features, including the TNM staging system. Although the TNM system can work well as a prognostication tool in some cancer types, its prognostic value in uveal melanoma has been disappoi...

We would like to congratulate Skinner and colleagues on their recent article, in which they perform a thorough statistical comparison of multiple uveal melanoma classification systems that are based on anatomic features, including the TNM staging system. Although the TNM system can work well as a prognostication tool in some cancer types, its prognostic value in uveal melanoma has been disappoi...

We would like to congratulate Skinner and colleagues on their recent article, in which they perform a thorough statistical comparison of multiple uveal melanoma classification systems that are based on anatomic features, including the TNM staging system. Although the TNM system can work well as a prognostication tool in some cancer types, its prognostic value in uveal melanoma has been disappoi...

We would like to congratulate Skinner and colleagues on their recent article, in which they perform a thorough statistical comparison of multiple uveal melanoma classification systems that are based on anatomic features, including the TNM staging system. Although the TNM system can work well as a prognostication tool in some cancer types, its prognostic value in uveal melanoma has been disappoi...

PURPOSE Breast cancer arising in young women is correlated with inferior survival and higher incidence of negative clinicopathologic features. The biology driving this aggressive disease has yet to be defined. PATIENTS AND METHODS Clinically annotated, microarray data from 784 early-stage breast cancers were identified, and prospectively defined, age-specific cohorts (young: </= 45 years, n =...

OBJECTIVES/HYPOTHESIS To determine the incidence and clinical significance of TP53 and CDKN2a somatic mutations in never smokers with oral tongue squamous cell carcinoma (OTSCC). STUDY DESIGN Case series. METHODS Fifty-one paraffin-embedded tumors from never smokers with OTSCC were obtained. p53 and p16 expression was determined by immunohistochemical (IHC) staining. Tumor DNA was amplified...

We would like to congratulate Skinner and colleagues on their recent article, in which they perform a thorough statistical comparison of multiple uveal melanoma classification systems that are based on anatomic features, including the TNM staging system. Although the TNM system can work well as a prognostication tool in some cancer types, its prognostic value in uveal melanoma has been disappoi...