Rationale: Huntington disease (HD) is a progressive neurodegenerative disorder characterized by motor, cognitive and neuropsychiatric symptoms. HD is usually diagnosed by the appearance of motor deficits, resulting in skilled hand use disruption, gait abnormality, muscle wasting and choreatic movements. The BACHD transgenic rat model for HD represents a well-established transgenic rodent model ...

Bipedal locomotion and fine motility of hand and larynx of humans introduced musculoskeletal adaptations, new pyramidal, corticostriatal, corticobulbar, nigrostriatal, and cerebellar pathways and expansions of prefrontal, cingular, parieto-temporal and occipital cortices with derived new brain capabilities. All selectively degenerate in aged homo sapiens following 16 syndromic presentations: (1...

objectives: the objective of this study was to examine the psychometric properties of the ‘physical well-being, health and motor development inventory’ used to assess school readiness in ordinary and mentally retarded pre-school children. methods: a descriptive study examining validity was conducted using random sampling. two hundred students (160 ordinary and 40 mentally retarded children) wer...

The ability to use our hands is crucial in order to achieve the goals of almost all activities in everyday life. Most of us learn how to handle objects and adjust our hand and finger movements to perform increasingly difficult tasks during childhood and adolescence. This is what is expected, but what happens to our hand motor skills when the motor system is dama...

The authors studied motor behavior and primary motor (M1) and somatosensory (S1) cortical representations of movement during hand motor skill acquisition over 3 weeks. During four functional MRI sessions 1 week apart, subjects performed simple movements of single fingers and wrist, and a sequential movement of the middle three fingers, contrasted with rest. Half of the subjects practiced the se...

OBJECTIVE To compare visual function and fine-motor control of full-term infants small-for-gestational age (SGA) and appropriate for gestational age (AGA), in the first three months. METHOD We evaluated prospectively 31 infants in the 1st month; 33 in the 2nd and 34 infants in the 3rd month, categorized as full-term; birth weight less than 10th percentile for SGA and 25th to 90th percentile f...

Populations of neurons in motor cortex engage in complex transient dynamics of large amplitude during the execution of limb movements. Traditional network models with stochastically assigned synapses cannot reproduce this behavior. Here we introduce a class of cortical architectures with strong and random excitatory recurrence that is stabilized by intricate, fine-tuned inhibition, optimized fr...

Grasping an object involves shaping the hand and fingers in relation to the object's physical properties. Following object contact, it also requires a fine adjustment of grasp forces for secure manipulation. Earlier studies suggest that the control of hand shaping and grasp force involve partially segregated motor cortical networks. However, it is still unclear how information originating from ...

Right-handers tend to associate “good” with the right side of space and “bad” with the left. This implicit association appears to arise from the way people perform actions, more or less fluently, with their right and left hands. Here we tested whether observing manual actions performed with greater or lesser fluency can affect observers’ space-valence associations. In two experiments, we assign...

The Nine Hole Peg Test (NHPT) is routinely used in clinical environments to evaluate a patient’s fine hand control. A physician measures the total time required to insert nine pegs into nine holes and obtains information on the dexterity of the patient. Even though this method is simple and known to be reliable, using a virtual environment with haptic feedback instead of the classical device co...