Hairless mice were treated in vivo with empty phospholipid and ‘skin lipid’ liposomes, respectively. The deposition of a hydrophobic drug (hydrocortisone) and a hydrophilic drug (inulin) was investigated in both treated and untreated skin. It was found that drugs should be encapsulated in liposomes or at least be administered together with the lipid, to achieve targeted drug delivery. Pretreatm...

By laser induced breakdown spectroscopy (LIBS) analysis of epidermal lesion and dermis tissue pellets of hairless mouse, it is shown that Ca intensity in the epidermal lesion is higher than that in dermis, whereas Na and K intensities have an opposite tendency. It is demonstrated that epidermal lesion and normal dermis can be differentiated with high selectivity either by univariate or multivar...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 185 No. 7 1181–1194 www.jcb.org/cgi/doi/10.1083/jcb.200904161 JCB 1181 Correspondence to Hugo J. Bellen: [email protected] Abbreviations used in this paper: APF, after puparium formation; DHS, deoxyhypusine synthase; Dlg, Discs large; DOHH, deoxyhypusine hydroxylase; dsRNA, double-stranded RNA; FLP, flippase; FRT, FLP recombination ta...

A new species of the genus Haploperla, Haploperla triangulatasp. n., is described and illustrated from specimens collected in Qinghai province, China. Haploperla triangulata is characterized by the epiproct mostly sclerotized and hairless, sub-triangular in dorsal view and blunt at tip; and by the aedeagus with two median elliptical lobes ventrally. The new species is compared with its most sim...

In a screen designed to identify genes in the specification of epidermal cell fate in Arabidopsis primary roots we have isolated 8 new mutants that fall into 6 complementation groups corresponding to the 'root hairless' genes RHL1, RHL2 and RHL3 and the 'ectopic root hair' genes ERH1, ERH2 and ERH3. The erh2 mutant is allelic to pom1, a conditional root expansion mutant, and reveals a possible ...